Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types

Krzysztof M. Mrozik; Jimin Xiong; Peter S. Zilm; Stan Gronthos; P. Mark Bartold

doi:10.1007/978-94-007-2415-0_8

Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types

Krzysztof M. Mrozik, Jimin Xiong, Peter S. Zilm, Stan Gronthos, P. Mark Bartold

Blood Cancer Program

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The evolution of proteomics has led to its application in identifying biomarkers of biological processes and pathways including signal transduction and cell development. Proteomic technologies are increasingly utilized to define the molecular mechanisms controlling mesenchymal stem/stromal cell (MSC) self-renewal, multipotency and fate. Bone marrowderived MSCs are highly promising candidates in regenerative medicine based on their high proliferative capacity, multi-lineage differentiation potential and immunomodulatory properties. Recently, equivalent MSC-like populations have also been isolated from adipose, dental and various feto-maternal tissues. This chapter discusses the current technologies available for proteomic analysis and the studies performed on tissue-specific MSC-like populations to date.

Original language	English
Title of host publication	Stem Cells and Cancer Stem Cells, Volume 3
Subtitle of host publication	Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3
Publisher	Springer Netherlands
Pages	75-94
Number of pages	20
ISBN (Electronic)	9789400724150
ISBN (Print)	9789400724143
DOIs	https://doi.org/10.1007/978-94-007-2415-0_8
Publication status	Published or Issued - 1 Jan 2012

Keywords

Adipose tissue
Bone marrow
Dental pulp
Mesenchymal stem cells (MSCs)
Periodontal ligament
Proteomics
Umbilical cord blood

ASJC Scopus subject areas

General Medicine

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10.1007/978-94-007-2415-0_8

Cite this

Mrozik, K. M., Xiong, J., Zilm, P. S., Gronthos, S., & Bartold, P. M. (2012). Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types. In Stem Cells and Cancer Stem Cells, Volume 3: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3 (pp. 75-94). Springer Netherlands. https://doi.org/10.1007/978-94-007-2415-0_8

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abstract = "The evolution of proteomics has led to its application in identifying biomarkers of biological processes and pathways including signal transduction and cell development. Proteomic technologies are increasingly utilized to define the molecular mechanisms controlling mesenchymal stem/stromal cell (MSC) self-renewal, multipotency and fate. Bone marrowderived MSCs are highly promising candidates in regenerative medicine based on their high proliferative capacity, multi-lineage differentiation potential and immunomodulatory properties. Recently, equivalent MSC-like populations have also been isolated from adipose, dental and various feto-maternal tissues. This chapter discusses the current technologies available for proteomic analysis and the studies performed on tissue-specific MSC-like populations to date.",

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Mrozik, KM, Xiong, J, Zilm, PS, Gronthos, S & Bartold, PM 2012, Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types. in Stem Cells and Cancer Stem Cells, Volume 3: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3. Springer Netherlands, pp. 75-94. https://doi.org/10.1007/978-94-007-2415-0_8

Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types. / Mrozik, Krzysztof M.; Xiong, Jimin; Zilm, Peter S. et al.
Stem Cells and Cancer Stem Cells, Volume 3: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3. Springer Netherlands, 2012. p. 75-94.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Zilm, Peter S.

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Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types

Abstract

Keywords

ASJC Scopus subject areas

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