RAS mutation identifies a poor prognostic molecular subtype of therapy-related myeloid neoplasm

Chung Hoow Kok; Aref Al-Kali; Daniel Thomas; Rong He; Monika M. Kutyna; Hassan Alkhateeb; Kelly Lim; Antoine N. Saliba; Carla Toop; Aasiya Matin; Hamish Scott; Naseema Gangat; Anna Brown; Abhishek Mangaonkar; Christopher N. Hahn; Kebede Begna; Kevin Hung; Patricia Greipp; William J. Hogan; Mrinal Patnaik; Mithun Shah; Devendra K. Hiwase

doi:10.1182/bloodadvances.2025016374

RAS mutation identifies a poor prognostic molecular subtype of therapy-related myeloid neoplasm

Chung Hoow Kok, Aref Al-Kali, Daniel Thomas, Rong He, Monika M. Kutyna, Hassan Alkhateeb, Kelly Lim, Antoine N. Saliba, Carla Toop, Aasiya Matin, Hamish Scott, Naseema Gangat, Anna Brown, Abhishek Mangaonkar, Christopher N. Hahn, Kebede Begna, Kevin Hung, Patricia Greipp, William J. Hogan, Mrinal PatnaikMithun Shah, Devendra K. Hiwase

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	3814-3818
Number of pages	5
Journal	Blood Advances
Volume	9
Issue number	15
DOIs	https://doi.org/10.1182/bloodadvances.2025016374
Publication status	Published or Issued - 12 Aug 2025

Keywords

RAS mutation
Myeloid neoplasm
t-MN
NRAS
KRAS
AML
myelodysplastic syndromes

ASJC Scopus subject areas

Hematology

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10.1182/bloodadvances.2025016374

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Kok, C. H., Al-Kali, A., Thomas, D., He, R., Kutyna, M. M., Alkhateeb, H., Lim, K., Saliba, A. N., Toop, C., Matin, A., Scott, H., Gangat, N., Brown, A., Mangaonkar, A., Hahn, C. N., Begna, K., Hung, K., Greipp, P., Hogan, W. J., ... Hiwase, D. K. (2025). RAS mutation identifies a poor prognostic molecular subtype of therapy-related myeloid neoplasm. Blood Advances, 9(15), 3814-3818. https://doi.org/10.1182/bloodadvances.2025016374

@article{7ab4569d79014144b4883dfb855fdcaa,

title = "RAS mutation identifies a poor prognostic molecular subtype of therapy-related myeloid neoplasm",

keywords = "RAS mutation, Myeloid neoplasm, t-MN, NRAS, KRAS, AML, myelodysplastic syndromes",

author = "Kok, \{Chung Hoow\} and Aref Al-Kali and Daniel Thomas and Rong He and Kutyna, \{Monika M.\} and Hassan Alkhateeb and Kelly Lim and Saliba, \{Antoine N.\} and Carla Toop and Aasiya Matin and Hamish Scott and Naseema Gangat and Anna Brown and Abhishek Mangaonkar and Hahn, \{Christopher N.\} and Kebede Begna and Kevin Hung and Patricia Greipp and Hogan, \{William J.\} and Mrinal Patnaik and Mithun Shah and Hiwase, \{Devendra K.\}",

year = "2025",

month = aug,

day = "12",

doi = "10.1182/bloodadvances.2025016374",

language = "English",

volume = "9",

pages = "3814--3818",

journal = "Blood Advances",

issn = "2473-9529",

publisher = "American Society of Hematology",

number = "15",

}

Kok, CH, Al-Kali, A, Thomas, D, He, R, Kutyna, MM, Alkhateeb, H, Lim, K, Saliba, AN, Toop, C, Matin, A, Scott, H, Gangat, N, Brown, A, Mangaonkar, A, Hahn, CN, Begna, K, Hung, K, Greipp, P, Hogan, WJ, Patnaik, M, Shah, M & Hiwase, DK 2025, 'RAS mutation identifies a poor prognostic molecular subtype of therapy-related myeloid neoplasm', Blood Advances, vol. 9, no. 15, pp. 3814-3818. https://doi.org/10.1182/bloodadvances.2025016374

TY - JOUR

T1 - RAS mutation identifies a poor prognostic molecular subtype of therapy-related myeloid neoplasm

AU - Kok, Chung Hoow

AU - Al-Kali, Aref

AU - Thomas, Daniel

AU - He, Rong

AU - Kutyna, Monika M.

AU - Alkhateeb, Hassan

AU - Lim, Kelly

AU - Saliba, Antoine N.

AU - Toop, Carla

AU - Matin, Aasiya

AU - Scott, Hamish

AU - Gangat, Naseema

AU - Brown, Anna

AU - Mangaonkar, Abhishek

AU - Hahn, Christopher N.

AU - Begna, Kebede

AU - Hung, Kevin

AU - Greipp, Patricia

AU - Hogan, William J.

AU - Patnaik, Mrinal

AU - Shah, Mithun

AU - Hiwase, Devendra K.

PY - 2025/8/12

Y1 - 2025/8/12

KW - RAS mutation

KW - Myeloid neoplasm

KW - t-MN

KW - NRAS

KW - KRAS

KW - AML

KW - myelodysplastic syndromes

UR - https://www.scopus.com/pages/publications/105012101389

U2 - 10.1182/bloodadvances.2025016374

DO - 10.1182/bloodadvances.2025016374

M3 - Letter

C2 - 40402688

AN - SCOPUS:105012101389

SN - 2473-9529

VL - 9

SP - 3814

EP - 3818

JO - Blood Advances

JF - Blood Advances

IS - 15

ER -

RAS mutation identifies a poor prognostic molecular subtype of therapy-related myeloid neoplasm

Keywords

ASJC Scopus subject areas

Access to Document

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