Red Blood Cell Transfusions at 21 Days of Age or Older in Previously Transfusion-Naive Very Preterm Infants: Association with Neonatal Outcomes

Amy Keir, Khalid Aziz, Douglas McMillan, Luis Monterrosa, Cecil Ojah, Shoo Lee, Prakesh S. Shah

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Objective This study aims to assess the association of red blood cell (RBC) transfusion in a cohort of preterm infants with mortality, retinopathy of prematurity (ROP), and chronic lung disease (CLD) transfused at ≥ 21 days of life. Study Design and Methods This retrospective cohort study included infants born at < 30 weeks' gestation who survived ≥ 21 days, had not received any RBC transfusions before reaching 21 days of age, and were admitted to participating units in the Canadian neonatal network (2003-2009). Results Out of the 3,799 eligible infants, 3,309 infants did not receive RBC transfusion at ≥ 21 days of age, whereas 490 received transfusion at ≥ 21 days of age. Infants who did not receive RBC transfusion/s at ≥ 21 days of age had higher birth weight (p < 0.01) and higher gestational age at the time of birth (p < 0.01) as compared with those who received transfusion/s at ≥ 21 days of age. Receipt of RBC transfusion/s at ≥ 21 days of age was not associated with mortality (adjusted odds ratio [AOR] 1.20; 95% confidence interval [CI] 0.33-4.34) or severe ROP (AOR 1.02; 95% CI 0.59-1.77) but was associated with increased odds of CLD (AOR 1.78; 95% CI 1.43-2.22). Conclusion RBC transfusion/s at ≥ 21 days of age in previously transfusion-naive preterm infants was associated with increased odds of CLD but not with ROP or mortality.

Original languageEnglish
Pages (from-to)1139-1144
Number of pages6
JournalAmerican Journal of Perinatology
Issue number12
Publication statusPublished or Issued - 27 Apr 2015
Externally publishedYes


  • adverse effects
  • infant
  • newborn
  • premature
  • red blood cell transfusion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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