Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications

Natasha L. Grimsey, Juha R. Savinainen, Bala Attili, Muneer Ahamed

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Monoacylglycerol lipase (MAGL) is a major endocannabinoid hydrolyzing enzyme and can be regulated to control endogenous lipid levels in the brain. This review highlights the pharmacological roles and in vivo PET imaging of MAGL in brain.

Original languageEnglish
Pages (from-to)330-343
Number of pages14
JournalDrug Discovery Today
Volume25
Issue number2
DOIs
Publication statusPublished or Issued - Feb 2020
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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