TY - JOUR
T1 - Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity
AU - Wilms, Femke F.
AU - Vis, Jolande Y.
AU - Pattinaja, Desiree A.P.M.
AU - Kuin, Rosanna A.
AU - Stam, Monique C.
AU - Reuvers, Janine M.
AU - Mol, Ben Willem J.
PY - 2011/7
Y1 - 2011/7
N2 - Objective: The purpose of this study was to assess the relationship between neonatal respiratory morbidity and the interval between antenatal corticosteroids (ACS) administration and birth. Study Design: We performed a retrospective cohort study among women who had received ACS and delivered at <34 weeks of gestation. We categorized these women in 4 groups: ACS-to-delivery interval of 0-7, 8-14, 15-21, and 22-28 days. Multivariable logistic regression analysis assessed the association between the ACS-to-delivery interval and neonatal respiratory morbidity. Results: We included 254 neonates. Eighty-two neonates (32%) were intubated. In comparison with neonates with an ACS-to-delivery interval of 0-7 days, the risk for intubation was increased in all other groups (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.15.4; OR, 5.6; 95% CI, 1.818; and OR, 4.8; 95% CI, 0.7132, not statistically significant, respectively). Conclusion: The effect of ACS decreases when the ACS-to-delivery interval exceeds 7 days. The first administration of ACS should be considered carefully.
AB - Objective: The purpose of this study was to assess the relationship between neonatal respiratory morbidity and the interval between antenatal corticosteroids (ACS) administration and birth. Study Design: We performed a retrospective cohort study among women who had received ACS and delivered at <34 weeks of gestation. We categorized these women in 4 groups: ACS-to-delivery interval of 0-7, 8-14, 15-21, and 22-28 days. Multivariable logistic regression analysis assessed the association between the ACS-to-delivery interval and neonatal respiratory morbidity. Results: We included 254 neonates. Eighty-two neonates (32%) were intubated. In comparison with neonates with an ACS-to-delivery interval of 0-7 days, the risk for intubation was increased in all other groups (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.15.4; OR, 5.6; 95% CI, 1.818; and OR, 4.8; 95% CI, 0.7132, not statistically significant, respectively). Conclusion: The effect of ACS decreases when the ACS-to-delivery interval exceeds 7 days. The first administration of ACS should be considered carefully.
KW - corticosteroid
KW - preterm delivery
KW - respiratory morbidity
UR - http://www.scopus.com/inward/record.url?scp=80955178388&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2011.03.035
DO - 10.1016/j.ajog.2011.03.035
M3 - Article
C2 - 21620358
AN - SCOPUS:80955178388
SN - 0002-9378
VL - 205
SP - 49.e1-49.e7
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1
ER -