Abstract
Resistant hypertension is a growing cardiovascular problem worldwide and despite significant pharmacological advances medical
management of the pathology remains challenging. In early clinical trials renal denervation, a catheter based therapy that denervates
renal afferent and efferent sympathetic nervous system has demonstrated significant blood pressure reduction in patients with resistant
hypertension. However, Symplicity HTN-3, the recent randomized controlled trial has challenged the efficacy of the procedure and
underscored that there remain key issues to overcome before the procedure can be used as a standard of care in patients with
resistant hypertension. This review provides a balanced update on the recent preclinical and clinical studies in the field and, focuses
on the important advances required to enhance the forward progression of a technique that has the potential to treat this highly
heterogeneous pathology.
management of the pathology remains challenging. In early clinical trials renal denervation, a catheter based therapy that denervates
renal afferent and efferent sympathetic nervous system has demonstrated significant blood pressure reduction in patients with resistant
hypertension. However, Symplicity HTN-3, the recent randomized controlled trial has challenged the efficacy of the procedure and
underscored that there remain key issues to overcome before the procedure can be used as a standard of care in patients with
resistant hypertension. This review provides a balanced update on the recent preclinical and clinical studies in the field and, focuses
on the important advances required to enhance the forward progression of a technique that has the potential to treat this highly
heterogeneous pathology.
| Original language | English |
|---|---|
| Pages (from-to) | 5-8 |
| Journal | Journal of Advanced Therapies and Medical Innovation Sciences |
| Publication status | Published or Issued - 2016 |
Keywords
- Percutaneous renal sympathetic denervation
- Resistant hypertension
- Radio-frequency ablation
- Sympathetic nervous system