TY - JOUR
T1 - RENAL TRANSPLANTATION AND A POSITIVE SEROLOGICAL CROSS-MATCH
AU - Morris, P. J.
AU - Oliver, D. O.
AU - Williams, K.
AU - Ting, A.
AU - Bishop, M.
AU - Dunnill, M. S.
N1 - Funding Information:
additional sugar or going without food altogether, is not associated with the same risk of developing hypoglycx- mia. Since very few people know the alcohol content of their drinks, let alone their carbohydrate content, our observations are potentially of concern, not least to those involved with motor-car and other aspects of safety. We should like to thank Dr John Wright and members of the inves- tigation unit and clinical biochemistry department of St. Luke’s Hos- pital, Guildford, for technical help and the Clinical Biochemistry Fund, University of Surrey, for financial support.
PY - 1977/6/18
Y1 - 1977/6/18
N2 - A renal transplant involving a recipient with a positive serological cross-match against donor lymphocytes generally results in hyperacute rejection of the graft. 13 cadaveric renal transplants were performed in recipients with a known positive serological cross-match against donor B lymphocytes. 12 of these serological cross-matches were positive against donor blood, node, or spleen lymphocytes, but the reactivity was directed against donor B lymphocytes only. 3 transplants failed, 2 because of rejection and 1 because of renal-artery thrombosis. 10 transplants are functioning, 6 to 42 weeks after the operation. Of these 10 successful grafts, 3 had no acute rejection episodes, while 7 had an early acute rejection episode which responded to treatment. Histologically, the grafts showed a cellular rejection, similar to that in enhanced renal allografts in the rat. It is possible to transplant a kidney in a high-risk patient with a positive B lymphocyte cross-match with a low risk of failure. In addition active enhancement of the graft might sometimes occur.
AB - A renal transplant involving a recipient with a positive serological cross-match against donor lymphocytes generally results in hyperacute rejection of the graft. 13 cadaveric renal transplants were performed in recipients with a known positive serological cross-match against donor B lymphocytes. 12 of these serological cross-matches were positive against donor blood, node, or spleen lymphocytes, but the reactivity was directed against donor B lymphocytes only. 3 transplants failed, 2 because of rejection and 1 because of renal-artery thrombosis. 10 transplants are functioning, 6 to 42 weeks after the operation. Of these 10 successful grafts, 3 had no acute rejection episodes, while 7 had an early acute rejection episode which responded to treatment. Histologically, the grafts showed a cellular rejection, similar to that in enhanced renal allografts in the rat. It is possible to transplant a kidney in a high-risk patient with a positive B lymphocyte cross-match with a low risk of failure. In addition active enhancement of the graft might sometimes occur.
UR - http://www.scopus.com/inward/record.url?scp=0017414421&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(77)91322-8
DO - 10.1016/S0140-6736(77)91322-8
M3 - Article
C2 - 68386
AN - SCOPUS:0017414421
SN - 0140-6736
VL - 309
SP - 1288
EP - 1291
JO - The Lancet
JF - The Lancet
IS - 8025
ER -