@article{00db23fe514045f98c6c26c2f02a2090,
title = "Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure",
abstract = "Background: The C452F mutation in the mitochondrial fission protein Drp1 leads to heart failure through an unknown mechanism. Results: C452F impairs Drp1 disassembly, leading to impaired mitophagy, failed bioenergetics, and inflammation. Conclusion: Drp1-mediated mitochondrial fission is essential for normal cardiac function. Significance: Mutations in mitochondrial quality control proteins are a likely cause of human cardiomyopathy.",
author = "Cahill, {Thomas J.} and Vincenzo Leo and Matthew Kelly and Alexander Stockenhuber and Kennedy, {Nolan W.} and Leyuan Bao and Grazia Cereghetti and Harper, {Andrew R.} and Gabor Czibik and Chunyan Lao and Mohamed Bellahcene and Violetta Steeples and Safar Ghaffari and Arash Yavari and Alice Mayer and Joanna Poulton and Ferguson, {David J.P.} and Luca Scorrano and Hettiarachchi, {Nishani T.} and Chris Peers and John Boyle and Hill, {R. Blake} and Alison Simmons and Hugh Watkins and Dear, {T. Neil} and Houman Ashrafian",
note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",
year = "2015",
month = oct,
day = "23",
doi = "10.1074/jbc.M115.665695",
language = "English",
volume = "290",
pages = "25907--25919",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "43",
}