Role of IL-17 and IL-22 in autoimmunity and cancer

S. J. Blake, M. W.L. Teng

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The dysregulation of inflammatory cytokines can cause a variety of diseases, such as autoimmunity and cancer. Since their identification in 2005, Th17 cells and its signature cytokine IL-17, have been implicated in the pathogenesis of autoimmune diseases such as psoriasis and rheumatoid arthritis (RA), and inflammatory associated cancers such as colorectal carcinoma (CRC). Recently, IL-22 a Th17 related cytokine has been shown to be pathogenic in psoriasis and RA. In this review, we will summarize the biological functions of IL-17 and IL-22, their role in autoimmune diseases and briefly review results from clinical trials targeting IL-17 or its receptor for the treatment of autoimmune diseases. Next, we will discuss pre-clinical and clinical data supporting the rationale of targeting other cytokines implicated in the Th17/IL-17 pathway, such as IL-22 and IL-23. Finally, we discuss the role of IL-17, and in particularly IL-22 in tumour immunity and possible therapeutic interventions.

Original languageEnglish
Pages (from-to)41-50
Number of pages10
JournalActas Dermo-Sifiliograficas
Volume105
DOIs
Publication statusPublished or Issued - 2014
Externally publishedYes

Keywords

  • Autoimmunity
  • Cancer
  • IL-22

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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