Role of membranes in the activities of antimicrobial cationic peptides

Robert E.W. Hancock; Annett Rozek

doi:10.1016/S0378-1097(01)00480-3

Role of membranes in the activities of antimicrobial cationic peptides

Robert E.W. Hancock, Annett Rozek

Research output: Contribution to journal › Short survey › peer-review

526 Citations (Scopus)

Abstract

Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.

Original language	English
Pages (from-to)	143-149
Number of pages	7
Journal	FEMS Microbiology Letters
Volume	206
Issue number	2
DOIs	https://doi.org/10.1016/S0378-1097(01)00480-3
Publication status	Published or Issued - 10 Jan 2002
Externally published	Yes

Keywords

Antimicrobial peptide
Cationic peptide
Membrane
Mode of action
Model Membrane

ASJC Scopus subject areas

Microbiology
Molecular Biology
Genetics

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10.1016/S0378-1097(01)00480-3

Cite this

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title = "Role of membranes in the activities of antimicrobial cationic peptides",

abstract = "Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.",

keywords = "Antimicrobial peptide, Cationic peptide, Membrane, Mode of action, Model Membrane",

author = "Hancock, {Robert E.W.} and Annett Rozek",

note = "Funding Information: The authors{\textquoteright} own research has been supported by the Canadian Bacterial Diseases Network and the Canadian Cystic Fibrosis Foundation{\textquoteright}s SPARx program. R.E.W.H. holds a Canada Research Chair in Microbiology and A.R. is the recipient of a CIHR postdoctoral fellowship.",

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T1 - Role of membranes in the activities of antimicrobial cationic peptides

AU - Hancock, Robert E.W.

AU - Rozek, Annett

N1 - Funding Information: The authors’ own research has been supported by the Canadian Bacterial Diseases Network and the Canadian Cystic Fibrosis Foundation’s SPARx program. R.E.W.H. holds a Canada Research Chair in Microbiology and A.R. is the recipient of a CIHR postdoctoral fellowship.

PY - 2002/1/10

Y1 - 2002/1/10

N2 - Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.

AB - Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.

KW - Antimicrobial peptide

KW - Cationic peptide

KW - Membrane

KW - Mode of action

KW - Model Membrane

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U2 - 10.1016/S0378-1097(01)00480-3

DO - 10.1016/S0378-1097(01)00480-3

M3 - Short survey

C2 - 11814654

AN - SCOPUS:0037050278

SN - 0378-1097

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EP - 149

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 2

ER -

Role of membranes in the activities of antimicrobial cationic peptides

Abstract

Keywords

ASJC Scopus subject areas

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