Role of membranes in the activities of antimicrobial cationic peptides

Robert E.W. Hancock, Annett Rozek

Research output: Contribution to journalShort surveypeer-review

518 Citations (Scopus)


Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalFEMS Microbiology Letters
Issue number2
Publication statusPublished or Issued - 10 Jan 2002
Externally publishedYes


  • Antimicrobial peptide
  • Cationic peptide
  • Membrane
  • Mode of action
  • Model Membrane

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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