TY - JOUR
T1 - Role of the β common (βc) family of cytokines in health and disease
AU - Hercus, Timothy R.
AU - Kan, Winnie L.T.
AU - Broughton, Sophie E.
AU - Tvorogov, Denis
AU - Ramshaw, Hayley S.
AU - Sandow, Jarrod J.
AU - Nero, Tracy L.
AU - Dhagat, Urmi
AU - Thompson, Emma J.
AU - Tung Shing, Karen S.Cheung
AU - McKenzie, Duncan R.
AU - Wilson, Nicholas J.
AU - Owczarek, Catherine M.
AU - Vairo, Gino
AU - Nash, Andrew D.
AU - Tergaonkar, Vinay
AU - Hughes, Timothy
AU - Ekert, Paul G.
AU - Samuel, Michael S.
AU - Bonder, Claudine S.
AU - Grimbaldeston, Michele A.
AU - Parker, Michael W.
AU - Lopez, Angel F.
N1 - Funding Information:
This work is supported by grants from the National Health and Medical Research Council of Australia (NHMRC), the Australian Cancer Research Foundation, the Leukemia Foundation of Australia, and CSL Limited, as well as funding from Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme.
PY - 2018/6
Y1 - 2018/6
N2 - The b common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use bc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the bc cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease. This review will focus on the emerging biological roles for the bc cytokines, our progress toward understanding the mechanisms of receptor assembly and signaling, and the application of this knowledge to develop exciting new therapeutic approaches against human disease.
AB - The b common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use bc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the bc cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease. This review will focus on the emerging biological roles for the bc cytokines, our progress toward understanding the mechanisms of receptor assembly and signaling, and the application of this knowledge to develop exciting new therapeutic approaches against human disease.
UR - http://www.scopus.com/inward/record.url?scp=85047995628&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a028514
DO - 10.1101/cshperspect.a028514
M3 - Article
C2 - 28716883
AN - SCOPUS:85047995628
VL - 10
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
SN - 1943-0264
IS - 6
M1 - a028514
ER -