TY - JOUR
T1 - SHED
T2 - Stem cells from human exfoliated deciduous teeth
AU - Miura, Masako
AU - Gronthos, Stan
AU - Zhao, Mingrui
AU - Lu, Bai
AU - Fisher, Larry W.
AU - Robey, Pamela Gehron
AU - Shi, Songtao
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/5/13
Y1 - 2003/5/13
N2 - To isolate high-quality human postnatal stem cells from accessible resources is an important goal for stem-cell research. In this study we found that exfoliated human deciduous tooth contains multipotent stem cells [stem cells from human exfoliated deciduous teeth (SHED)]. SHED were identified to be a population of highly proliferative, clonogenic cells capable of differentiating into a variety of cell types including neural cells, adipocytes, and odontoblasts. After in vivo transplantation, SHED were found to be able to induce bone formation, generate dentin, and survive in mouse brain along with expression of neural markers. Here we show that a naturally exfoliated human organ contains a population of stem cells that are completely different from previously identified stem cells. SHED are not only derived from a very accessible tissue resource but are also capable of providing enough cells for potential clinical application. Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering.
AB - To isolate high-quality human postnatal stem cells from accessible resources is an important goal for stem-cell research. In this study we found that exfoliated human deciduous tooth contains multipotent stem cells [stem cells from human exfoliated deciduous teeth (SHED)]. SHED were identified to be a population of highly proliferative, clonogenic cells capable of differentiating into a variety of cell types including neural cells, adipocytes, and odontoblasts. After in vivo transplantation, SHED were found to be able to induce bone formation, generate dentin, and survive in mouse brain along with expression of neural markers. Here we show that a naturally exfoliated human organ contains a population of stem cells that are completely different from previously identified stem cells. SHED are not only derived from a very accessible tissue resource but are also capable of providing enough cells for potential clinical application. Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering.
KW - Adipocyte
KW - Bone regeneration
KW - Dental pulp stem cell
KW - Neural differentiation
KW - Odontoblast
UR - http://www.scopus.com/inward/record.url?scp=0037687418&partnerID=8YFLogxK
U2 - 10.1073/pnas.0937635100
DO - 10.1073/pnas.0937635100
M3 - Article
C2 - 12716973
AN - SCOPUS:0037687418
SN - 0027-8424
VL - 100
SP - 5807
EP - 5812
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 10
ER -