Simultaneous triple point-of-care testing for HIV, syphilis and hepatitis B virus to prevent mother-to-child transmission in India

N. P. Pai, J. Kurji, A. Singam, R. Barick, Y. Jafari, M. B. Klein, S. Chhabra, P. Shivkumar

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

An innovative simultaneous triple point-of-care (STPOC) screening strategy for syphilis, hepatitis B and HIV with Determine® tests was offered to pregnant women presenting for antenatal care and evaluated for feasibility and preference in rural India. Of 1066 participants approached, 1046 consented, of which 1002 (96.0%) completed the strategy. Only 9% reported any history of testing in their current pregnancy. With STPOC screening, 989 women (98.7%) tested negative and 13 had preliminary positive results for infection. The total time taken was 45 minutes per participant. Mothers and infants were provided prophylaxis/treatment for HIV, syphilis and hepatitis B, with interventions initiated within 3-5 days. STPOC was preferred by 99.3% (95%CI: 98.8-99.8%) of participants, facilitated early simultaneous screening for the three infections, timely initiation of prophylaxis/treatment and was feasible in this rural setting. These data suggest that multiplexed STPOC screening for syphilis, hepatitis B and HIV in pregnancy would be desirable for women in rural India.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalInternational Journal of STD and AIDS
Volume23
Issue number5
DOIs
Publication statusPublished or Issued - May 2012
Externally publishedYes

Keywords

  • Antenatal care
  • HIV
  • Hepatitis B
  • India
  • Point-of-care test
  • Pregnancy
  • Rural
  • Screening
  • Syphilis

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Cite this