Soy intake is associated with lowering blood pressure in adults: A systematic review and meta-analysis of randomized double-blind placebo-controlled trials

Zahra Mosallanezhad, Marzieh Mahmoodi, Sara Ranjbar, Razieh Hosseini, Cain C.T. Clark, Kristin Carson-Chahhoud, Zahra Norouzi, Ali Abbasian, Zahra Sohrabi, Mohammad Jalali

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


Background: Soy has several beneficial effects on cardiovascular disease (CVD); however, results of clinical trial studies are equivocal. Thus, the present study sought to discern the efficacy of soy intake on blood pressure. Methods: The search process was conducted in PubMed, Scopus, Web of Science, and Cochrane Library, to ascertain studies investigating the efficacy of soy intake on blood pressure in adults, published up to June 2020. A random-effects model was applied to pool mean difference and 95 % confidence interval (CI). Begg's and Egger's methods were conducted to assess publication bias. Results: Pooled effects from 17 effect sizes revealed a significant improvement in systolic blood pressure (SBP) (−1.70; −3.34 to −0.06 mmHg; I2 = 45.4 %) and diastolic blood pressure (DBP) (−1.27; −2.36 to −0.19 mmHg, I2 = 43.9 %) following soy consumption, in comparison with controls. Subgroup analysis demonstrated a reduction in both SBP and DBP in younger participants with lower baseline DBP and intervention durations of <16 weeks. Conclusion: Our results suggest that soy intake is associated with an ameliorating effect on blood pressure in adults.

Original languageEnglish
Article number102692
JournalComplementary Therapies in Medicine
Publication statusPublished or Issued - Jun 2021
Externally publishedYes


  • Blood pressure
  • Hypertension
  • Meta-analysis
  • Review
  • Soy

ASJC Scopus subject areas

  • Complementary and Manual Therapy
  • Complementary and alternative medicine
  • Advanced and Specialised Nursing

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