TY - JOUR
T1 - Subclinical left ventricular dysfunction and coronary atherosclerosis in asymptomatic patients with type 2 diabetes
AU - Scholte, Arthur J.H.A.
AU - Nucifora, Gaetano
AU - Delgado, Victoria
AU - Djaberi, Roxana
AU - Boogers, Mark J.
AU - Schuijf, Joanne D.
AU - Kharagjitsingh, Antje V.
AU - Jukema, J. Wouter
AU - Van Der Wall, Ernst E.
AU - Kroft, Lucia J.
AU - De Roos, Albert
AU - Bax, Jeroen J.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/2
Y1 - 2011/2
N2 - AimsThe aim of the present study was to evaluate whether subclinical left ventricular (LV) systolic dysfunction is independently related to subclinical coronary atherosclerosis in type 2 diabetic patients and if it could provide incremental information over baseline characteristics to identify high-risk patients.Methods and resultsA total of 234 asymptomatic, type 2 diabetic patients without overt LV systolic dysfunction underwent coronary artery calcium (CAC) scoring and two-dimensional echocardiography. The LV global longitudinal strain (GLS) was assessed using automated function imaging. Patients with coronary atherosclerosis (CAC > 0; n 139) had more impaired GLS when compared with patients without coronary atherosclerosis (CAC 0; n 95; -18.0 ± 2.8 vs. -16.3 ± 3.0, P < 0.001). At multivariate analysis, male gender, hypertension, hypercholesterolaemia, and the LV GLS were independently associated with coronary atherosclerosis. The addition of the LV GLS to other selected independent clinical variables significantly improved the ability to predict coronary atherosclerosis in these patients (χ2 58.92; P=0.001).ConclusionType 2 diabetic patients with coronary atherosclerosis showed a more impaired LV GLS compared with patients without coronary atherosclerosis. The presence of subclinical LV systolic dysfunction provides significant incremental value for the identification of diabetic patients having coronary atherosclerosis.
AB - AimsThe aim of the present study was to evaluate whether subclinical left ventricular (LV) systolic dysfunction is independently related to subclinical coronary atherosclerosis in type 2 diabetic patients and if it could provide incremental information over baseline characteristics to identify high-risk patients.Methods and resultsA total of 234 asymptomatic, type 2 diabetic patients without overt LV systolic dysfunction underwent coronary artery calcium (CAC) scoring and two-dimensional echocardiography. The LV global longitudinal strain (GLS) was assessed using automated function imaging. Patients with coronary atherosclerosis (CAC > 0; n 139) had more impaired GLS when compared with patients without coronary atherosclerosis (CAC 0; n 95; -18.0 ± 2.8 vs. -16.3 ± 3.0, P < 0.001). At multivariate analysis, male gender, hypertension, hypercholesterolaemia, and the LV GLS were independently associated with coronary atherosclerosis. The addition of the LV GLS to other selected independent clinical variables significantly improved the ability to predict coronary atherosclerosis in these patients (χ2 58.92; P=0.001).ConclusionType 2 diabetic patients with coronary atherosclerosis showed a more impaired LV GLS compared with patients without coronary atherosclerosis. The presence of subclinical LV systolic dysfunction provides significant incremental value for the identification of diabetic patients having coronary atherosclerosis.
KW - Coronary atherosclerosis
KW - LV subclinical dysfunction
KW - Speckle tracking imaging analysis
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=79951647180&partnerID=8YFLogxK
U2 - 10.1093/ejechocard/jeq165
DO - 10.1093/ejechocard/jeq165
M3 - Article
C2 - 21106580
AN - SCOPUS:79951647180
SN - 1525-2167
VL - 12
SP - 148
EP - 155
JO - European Journal of Echocardiography
JF - European Journal of Echocardiography
IS - 2
ER -