Subclinical left ventricular dysfunction and coronary atherosclerosis in asymptomatic patients with type 2 diabetes

Arthur J.H.A. Scholte, Gaetano Nucifora, Victoria Delgado, Roxana Djaberi, Mark J. Boogers, Joanne D. Schuijf, Antje V. Kharagjitsingh, J. Wouter Jukema, Ernst E. Van Der Wall, Lucia J. Kroft, Albert De Roos, Jeroen J. Bax

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


AimsThe aim of the present study was to evaluate whether subclinical left ventricular (LV) systolic dysfunction is independently related to subclinical coronary atherosclerosis in type 2 diabetic patients and if it could provide incremental information over baseline characteristics to identify high-risk patients.Methods and resultsA total of 234 asymptomatic, type 2 diabetic patients without overt LV systolic dysfunction underwent coronary artery calcium (CAC) scoring and two-dimensional echocardiography. The LV global longitudinal strain (GLS) was assessed using automated function imaging. Patients with coronary atherosclerosis (CAC > 0; n 139) had more impaired GLS when compared with patients without coronary atherosclerosis (CAC 0; n 95; -18.0 ± 2.8 vs. -16.3 ± 3.0, P < 0.001). At multivariate analysis, male gender, hypertension, hypercholesterolaemia, and the LV GLS were independently associated with coronary atherosclerosis. The addition of the LV GLS to other selected independent clinical variables significantly improved the ability to predict coronary atherosclerosis in these patients (χ2 58.92; P=0.001).ConclusionType 2 diabetic patients with coronary atherosclerosis showed a more impaired LV GLS compared with patients without coronary atherosclerosis. The presence of subclinical LV systolic dysfunction provides significant incremental value for the identification of diabetic patients having coronary atherosclerosis.

Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalEuropean Journal of Echocardiography
Issue number2
Publication statusPublished or Issued - Feb 2011
Externally publishedYes


  • Coronary atherosclerosis
  • LV subclinical dysfunction
  • Speckle tracking imaging analysis
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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