Successful salvage of RAEB/AML relapsing early post allograft with FLAG-Ida conditioned mini-allograft: A report of two cases

C. H. Hui; P. Bardy; T. Hughes; N. Horvath; L. B. To

doi:10.1046/j.1365-2257.2001.00359.x

Successful salvage of RAEB/AML relapsing early post allograft with FLAG-Ida conditioned mini-allograft: A report of two cases

C. H. Hui, P. Bardy, T. Hughes, N. Horvath, L. B. To

Blood Cancer Program

Research output: Contribution to journal › Article › peer-review

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Abstract

Management options are often limited for patients with AML or high grade myelodysplasia (MDS) relapsing within a year of allogeneic transplantation. We report, in two such patients, the use of re-induction with FLAG-Ida chemotherapy, followed by the infusion of GCSF-mobilized blood stem cells from the same HLA-matched donor. Both patients achieved durable complete remissions with good quality of life and longer disease-free survival than after the first myeloablative allografts. This mini-allograft approach offers a practical, well-tolerated salvage and a potentially curative treatment for relapsed AML/high grade MDS patients failing a first conventional myeloablative allogeneic transplants.

Original language	English
Pages (from-to)	135-138
Number of pages	4
Journal	Clinical and Laboratory Haematology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2257.2001.00359.x
Publication status	Published or Issued - 23 Aug 2001

Keywords

FLAG-Ida
Mini-allograft
Relapsed AML
Second allograft

ASJC Scopus subject areas

Hematology

Access to Document

10.1046/j.1365-2257.2001.00359.x

Link to publication in Scopus

Cite this

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abstract = "Management options are often limited for patients with AML or high grade myelodysplasia (MDS) relapsing within a year of allogeneic transplantation. We report, in two such patients, the use of re-induction with FLAG-Ida chemotherapy, followed by the infusion of GCSF-mobilized blood stem cells from the same HLA-matched donor. Both patients achieved durable complete remissions with good quality of life and longer disease-free survival than after the first myeloablative allografts. This mini-allograft approach offers a practical, well-tolerated salvage and a potentially curative treatment for relapsed AML/high grade MDS patients failing a first conventional myeloablative allogeneic transplants.",

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