[18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): Application to 6-[18F]fluoro-l-DOPA

Ida S.R. Stenhagen; Anna K. Kirjavainen; Sarita J. Forsback; Charlotte G. Jørgensen; Edward G. Robins; Sajinder K. Luthra; Olof Solin; Véronique Gouverneur

doi:10.1039/c2cc38646a

[¹⁸F]Fluorination of an arylboronic ester using [¹⁸F]selectfluor bis(triflate): Application to 6-[¹⁸F]fluoro-l-DOPA

Ida S.R. Stenhagen, Anna K. Kirjavainen, Sarita J. Forsback, Charlotte G. Jørgensen, Edward G. Robins, Sajinder K. Luthra, Olof Solin, Véronique Gouverneur

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

The Ag-mediated electrophilic [¹⁸F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [¹⁸F]selectfluor bis(triflate) in acetone. The process gave 6-[18F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol^#x2212;1.

Original language	English
Pages (from-to)	1386-1388
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	14
DOIs	https://doi.org/10.1039/c2cc38646a
Publication status	Published or Issued - 22 Jan 2013
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c2cc38646a

Cite this

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title = "[18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): Application to 6-[18F]fluoro-l-DOPA",

abstract = "The Ag-mediated electrophilic [18F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [18F]selectfluor bis(triflate) in acetone. The process gave 6-[18F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol#x2212;1.",

author = "Stenhagen, {Ida S.R.} and Kirjavainen, {Anna K.} and Forsback, {Sarita J.} and J{\o}rgensen, {Charlotte G.} and Robins, {Edward G.} and Luthra, {Sajinder K.} and Olof Solin and V{\'e}ronique Gouverneur",

year = "2013",

month = jan,

day = "22",

doi = "10.1039/c2cc38646a",

language = "English",

volume = "49",

pages = "1386--1388",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "14",

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TY - JOUR

T1 - [18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate)

T2 - Application to 6-[18F]fluoro-l-DOPA

AU - Stenhagen, Ida S.R.

AU - Kirjavainen, Anna K.

AU - Forsback, Sarita J.

AU - Jørgensen, Charlotte G.

AU - Robins, Edward G.

AU - Luthra, Sajinder K.

AU - Solin, Olof

AU - Gouverneur, Véronique

PY - 2013/1/22

Y1 - 2013/1/22

N2 - The Ag-mediated electrophilic [18F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [18F]selectfluor bis(triflate) in acetone. The process gave 6-[18F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol#x2212;1.

AB - The Ag-mediated electrophilic [18F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [18F]selectfluor bis(triflate) in acetone. The process gave 6-[18F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol#x2212;1.

UR - http://www.scopus.com/inward/record.url?scp=84872719002&partnerID=8YFLogxK

U2 - 10.1039/c2cc38646a

DO - 10.1039/c2cc38646a

M3 - Article

C2 - 23321570

AN - SCOPUS:84872719002

SN - 1359-7345

VL - 49

SP - 1386

EP - 1388

JO - Chemical Communications

JF - Chemical Communications

IS - 14