Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide

Harriet Teare; Edward G. Robins; Erik Årstad; Sajinder K. Luthra; Véronique Gouverneur

doi:10.1039/b701177f

Synthesis and reactivity of [¹⁸F]-N-fluorobenzenesulfonimide

Harriet Teare, Edward G. Robins, Erik Årstad, Sajinder K. Luthra, Véronique Gouverneur

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

A novel [¹⁸F]NF reagent and two novel radiochemical transformations have been developed: [¹⁸F]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labelled fluorinated ketones and allylic fluorides respectively; the radiosynthesis of the fluorinated A ring of vitamin D ₃ has also been completed with success.

Original language	English
Pages (from-to)	2330-2332
Number of pages	3
Journal	Chemical Communications
Issue number	23
DOIs	https://doi.org/10.1039/b701177f
Publication status	Published or Issued - 2007
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/b701177f

Cite this

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abstract = "A novel [18F]NF reagent and two novel radiochemical transformations have been developed: [18F]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labelled fluorinated ketones and allylic fluorides respectively; the radiosynthesis of the fluorinated A ring of vitamin D 3 has also been completed with success.",

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AU - Robins, Edward G.

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AU - Gouverneur, Véronique

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AB - A novel [18F]NF reagent and two novel radiochemical transformations have been developed: [18F]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labelled fluorinated ketones and allylic fluorides respectively; the radiosynthesis of the fluorinated A ring of vitamin D 3 has also been completed with success.

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