Synthesis of a liphagal-frondosin c hybrid and speculation on the biosynthesis of the frondosins

Henry P. Pepper; Kevin K.W. Kuan; Jonathan H. George

doi:10.1021/ol300257v

Synthesis of a liphagal-frondosin c hybrid and speculation on the biosynthesis of the frondosins

Henry P. Pepper, Kevin K.W. Kuan, Jonathan H. George

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A hypothesis for the biosynthesis of the frondosins A-E is presented. Synthesis of a liphagal-frondosin C hybrid molecule has been achieved, with the frondosin C 6-7-5-6 ring system being constructed by a photochemical process that follows an intramolecular Paternò-Büchi reaction/fragmentation pathway.

Original language	English
Pages (from-to)	1524-1527
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	6
DOIs	https://doi.org/10.1021/ol300257v
Publication status	Published or Issued - 16 Mar 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol300257v

Cite this

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abstract = "A hypothesis for the biosynthesis of the frondosins A-E is presented. Synthesis of a liphagal-frondosin C hybrid molecule has been achieved, with the frondosin C 6-7-5-6 ring system being constructed by a photochemical process that follows an intramolecular Patern{\`o}-B{\"u}chi reaction/fragmentation pathway.",

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AU - Kuan, Kevin K.W.

AU - George, Jonathan H.

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Y1 - 2012/3/16

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AB - A hypothesis for the biosynthesis of the frondosins A-E is presented. Synthesis of a liphagal-frondosin C hybrid molecule has been achieved, with the frondosin C 6-7-5-6 ring system being constructed by a photochemical process that follows an intramolecular Paternò-Büchi reaction/fragmentation pathway.

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JO - Organic Letters

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Synthesis of a liphagal-frondosin c hybrid and speculation on the biosynthesis of the frondosins

Abstract

ASJC Scopus subject areas

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