Synthesis of a liphagal-frondosin c hybrid and speculation on the biosynthesis of the frondosins

Henry P. Pepper, Kevin K.W. Kuan, Jonathan H. George

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


A hypothesis for the biosynthesis of the frondosins A-E is presented. Synthesis of a liphagal-frondosin C hybrid molecule has been achieved, with the frondosin C 6-7-5-6 ring system being constructed by a photochemical process that follows an intramolecular Paternò-Büchi reaction/fragmentation pathway.

Original languageEnglish
Pages (from-to)1524-1527
Number of pages4
JournalOrganic Letters
Issue number6
Publication statusPublished or Issued - 16 Mar 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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