Synthetic antibiofilm peptides

César De La Fuente-Núñez, Marlon Henrique Cardoso, Elizabete De Souza Cândido, Octavio Luiz Franco, Robert E.W. Hancock

Research output: Contribution to journalArticlepeer-review

167 Citations (Scopus)

Abstract

Bacteria predominantly exist as multicellular aggregates known as biofilms that are associated with at least two thirds of all infections and exhibit increased adaptive resistance to conventional antibiotic therapies. Therefore, biofilms are major contributors to the global health problem of antibiotic resistance, and novel approaches to counter them are urgently needed. Small molecules of the innate immune system called host defense peptides (HDPs) have emerged as promising templates for the design of potent, broad-spectrum antibiofilm agents. Here, we review recent developments in the new field of synthetic antibiofilm peptides, including mechanistic insights, synergistic interactions with available antibiotics, and their potential as novel antimicrobials against persistent infections caused by biofilms. This article is part of a Special Issue entitled: Antimicrobial peptides edited by Karl Lohner and Kai Hilpert.

Original languageEnglish
Pages (from-to)1061-1069
Number of pages9
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1858
Issue number5
DOIs
Publication statusPublished or Issued - 1 May 2016
Externally publishedYes

Keywords

  • Antibiotic resistance
  • Biofilms
  • Biomaterials
  • Persistent infections
  • Synergy
  • Synthetic peptides

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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