Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

C. B. Ware; M. C. Horowitz; B. R. Renshaw; J. S. Hunt; D. Liggitt; S. A. Koblar; B. C. Gliniak; H. J. McKenna; T. Papayannopoulou; B. Thoma; L. Cheng; P. J. Donovan; J. J. Peschon; P. F. Bartlett; C. R. Willis; B. D. Wright; M. K. Carpenter; B. L. Davidson; D. P. Gearing

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

C. B. Ware, M. C. Horowitz, B. R. Renshaw, J. S. Hunt, D. Liggitt, S. A. Koblar, B. C. Gliniak, H. J. McKenna, T. Papayannopoulou, B. Thoma, L. Cheng, P. J. Donovan, J. J. Peschon, P. F. Bartlett, C. R. Willis, B. D. Wright, M. K. Carpenter, B. L. Davidson, D. P. Gearing

Research output: Contribution to journal › Article › peer-review

542 Citations (Scopus)

Abstract

The low-affinity receptor for leukemia inhibitory factor (LIFR) interacts with gp130 to induce an intracellular signal cascade. The LIFR-gp130 heterodimer is implicated in the function of diverse systems. Normal placentation is disrupted in LIFR mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord and brain stem. Late gestation fetal livers contain relatively high stores of glycogen, indicating a metabolic disorder. Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth.

Original language	English
Pages (from-to)	1283-1299
Number of pages	17
Journal	Development
Volume	121
Issue number	5
Publication status	Published or Issued - May 1995
Externally published	Yes

Keywords

Astrocytes
Glycogen store
Mouse
Osteoporosis
Primordial germ cell

ASJC Scopus subject areas

Molecular Biology
Developmental Biology

Cite this

Ware, C. B., Horowitz, M. C., Renshaw, B. R., Hunt, J. S., Liggitt, D., Koblar, S. A., Gliniak, B. C., McKenna, H. J., Papayannopoulou, T., Thoma, B., Cheng, L., Donovan, P. J., Peschon, J. J., Bartlett, P. F., Willis, C. R., Wright, B. D., Carpenter, M. K., Davidson, B. L., & Gearing, D. P. (1995). Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development, 121(5), 1283-1299.

@article{e749e158e8a74ad0b96e3be0e6eb2e02,

title = "Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death",

abstract = "The low-affinity receptor for leukemia inhibitory factor (LIFR) interacts with gp130 to induce an intracellular signal cascade. The LIFR-gp130 heterodimer is implicated in the function of diverse systems. Normal placentation is disrupted in LIFR mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord and brain stem. Late gestation fetal livers contain relatively high stores of glycogen, indicating a metabolic disorder. Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth.",

keywords = "Astrocytes, Glycogen store, Mouse, Osteoporosis, Primordial germ cell",

author = "Ware, {C. B.} and Horowitz, {M. C.} and Renshaw, {B. R.} and Hunt, {J. S.} and D. Liggitt and Koblar, {S. A.} and Gliniak, {B. C.} and McKenna, {H. J.} and T. Papayannopoulou and B. Thoma and L. Cheng and Donovan, {P. J.} and Peschon, {J. J.} and Bartlett, {P. F.} and Willis, {C. R.} and Wright, {B. D.} and Carpenter, {M. K.} and Davidson, {B. L.} and Gearing, {D. P.}",

year = "1995",

month = may,

language = "English",

volume = "121",

pages = "1283--1299",

journal = "Development",

issn = "0950-1991",

publisher = "Company of Biologists Ltd",

number = "5",

}

Ware, CB, Horowitz, MC, Renshaw, BR, Hunt, JS, Liggitt, D, Koblar, SA, Gliniak, BC, McKenna, HJ, Papayannopoulou, T, Thoma, B, Cheng, L, Donovan, PJ, Peschon, JJ, Bartlett, PF, Willis, CR, Wright, BD, Carpenter, MK, Davidson, BL & Gearing, DP 1995, 'Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death', Development, vol. 121, no. 5, pp. 1283-1299.

TY - JOUR

T1 - Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

AU - Ware, C. B.

AU - Horowitz, M. C.

AU - Renshaw, B. R.

AU - Hunt, J. S.

AU - Liggitt, D.

AU - Koblar, S. A.

AU - Gliniak, B. C.

AU - McKenna, H. J.

AU - Papayannopoulou, T.

AU - Thoma, B.

AU - Cheng, L.

AU - Donovan, P. J.

AU - Peschon, J. J.

AU - Bartlett, P. F.

AU - Willis, C. R.

AU - Wright, B. D.

AU - Carpenter, M. K.

AU - Davidson, B. L.

AU - Gearing, D. P.

PY - 1995/5

Y1 - 1995/5

N2 - The low-affinity receptor for leukemia inhibitory factor (LIFR) interacts with gp130 to induce an intracellular signal cascade. The LIFR-gp130 heterodimer is implicated in the function of diverse systems. Normal placentation is disrupted in LIFR mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord and brain stem. Late gestation fetal livers contain relatively high stores of glycogen, indicating a metabolic disorder. Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth.

AB - The low-affinity receptor for leukemia inhibitory factor (LIFR) interacts with gp130 to induce an intracellular signal cascade. The LIFR-gp130 heterodimer is implicated in the function of diverse systems. Normal placentation is disrupted in LIFR mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord and brain stem. Late gestation fetal livers contain relatively high stores of glycogen, indicating a metabolic disorder. Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth.

KW - Astrocytes

KW - Glycogen store

KW - Mouse

KW - Osteoporosis

KW - Primordial germ cell

UR - http://www.scopus.com/inward/record.url?scp=0029061551&partnerID=8YFLogxK

M3 - Article

C2 - 7789261

AN - SCOPUS:0029061551

SN - 0950-1991

VL - 121

SP - 1283

EP - 1299

JO - Development

JF - Development

IS - 5

ER -

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Cite this