The Asia-Pacific Society of Cardiology (APSC) expert committee consensus recommendations for assessment of suspected acute coronary syndrome using high-sensitivity cardiac troponin T in the emergency department

Wei Chieh Jack Tan, Kenji Inoue, Laila AbdelWareth, Evangelos Giannitsis, Sazzli Kasim, Masayuki Shiozaki, Tar Choon Aw, Federick Cheng, Ho Thuong Dung, Yi Heng Li, Swee Han Lim, Antonia Anna Lukito, Martin Than, Fang Yeh Chu, Tom Devasia, Chien Chang Lee, Arintaya Phrommintikul, Jong Chan Youn, Derek Chew

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7 Citations (Scopus)


The Asia-Pacific Society of Cardiology (APSC) high-sensitivity troponin T (hs-TnT) consensus recommendations and rapid algorithm were developed to provide guidance for healthcare professionals in the Asia-Pacific region on assessing patients with suspected acute coronary syndrome (ACS) using a hs-TnT assay. Experts from Asia-Pacific convened in 2 meetings to develop evidence-based consensus recommendations and an algorithm for appropriate use of the hs-TnT assay. The Expert Committee defined a cardiac troponin assay as a high-sensitivity assay if the total imprecision is ≤10% at the 99th percentile of the upper reference limit and measurable concentrations below the 99th percentile are attainable with an assay at a concentration value above the assay’s limit of detection for at least 50% of healthy individuals. Recommendations for single-measurement rule-out/rule-in cutoff values, as well as for serial measurements, were also developed. The Expert Committee also adopted similar hs-TnT cutoff values for men and women, recommended serial hs-TnT measurements for special populations, and provided guidance on the use of point-of-care troponin T devices in individuals suspected of ACS. These recommendations should be used in conjunction with all available clinical evidence when making the diagnosis of ACS.

Original languageEnglish
Pages (from-to)136-143
Number of pages8
JournalCirculation Journal
Issue number2
Publication statusPublished or Issued - 2020
Externally publishedYes


  • Acute coronary syndrome
  • Asia-Pacific
  • Consensus recommendations
  • High-sensitivity troponin T

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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