The bacterial outer membrane as a drug barrier

Robert E.W. Hancock

doi:10.1016/S0966-842X(97)81773-8

The bacterial outer membrane as a drug barrier

Robert E.W. Hancock

Research output: Contribution to journal › Review article › peer-review

333 Citations (Scopus)

Abstract

The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy with co-determinant resistance mechanisms, such as the periplasmic enzyme β-lactamase or active efflux mechanisms, bringing about antibiotic resistance.

Original language	English
Pages (from-to)	37-42
Number of pages	6
Journal	Trends in Microbiology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/S0966-842X(97)81773-8
Publication status	Published or Issued - Jan 1997
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

Access to Document

10.1016/S0966-842X(97)81773-8

Cite this

@article{c11c611d828148eaad7f757772b6b538,

title = "The bacterial outer membrane as a drug barrier",

abstract = "The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy with co-determinant resistance mechanisms, such as the periplasmic enzyme β-lactamase or active efflux mechanisms, bringing about antibiotic resistance.",

author = "Hancock, \{Robert E.W.\}",

year = "1997",

month = jan,

doi = "10.1016/S0966-842X(97)81773-8",

language = "English",

volume = "5",

pages = "37--42",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier Ltd",

number = "1",

}

TY - JOUR

T1 - The bacterial outer membrane as a drug barrier

AU - Hancock, Robert E.W.

PY - 1997/1

Y1 - 1997/1

N2 - The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy with co-determinant resistance mechanisms, such as the periplasmic enzyme β-lactamase or active efflux mechanisms, bringing about antibiotic resistance.

AB - The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy with co-determinant resistance mechanisms, such as the periplasmic enzyme β-lactamase or active efflux mechanisms, bringing about antibiotic resistance.

UR - https://www.scopus.com/pages/publications/0031050613

U2 - 10.1016/S0966-842X(97)81773-8

DO - 10.1016/S0966-842X(97)81773-8

M3 - Review article

C2 - 9025234

AN - SCOPUS:0031050613

SN - 0966-842X

VL - 5

SP - 37

EP - 42

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 1

ER -

The bacterial outer membrane as a drug barrier

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this