The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans

Luciana Ribeiro, João V. Busnello, Rita M. Cantor, Fiona Whelan, Pamela Whittaker, Panos Deloukas, Ma Li Wong, Julio Licinio

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87 Citations (Scopus)


The hypothesis that brain-derived neurotrophic factor (BDNF) is involved in the pathogenesis of major depression is supported by several research findings; however, genetic studies assessing the relationship between BDNF and psychiatric disorders have produced conflicting results. We examined the effect of a BDNF polymorphism on depression susceptibility in Mexican-Americans. The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005). Individuals homozygous for the major allele (GG) had an increased chance of being depressed (OR=1.7 95% CI 1.17-2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.

Original languageEnglish
Pages (from-to)1291-1293
Number of pages3
Issue number12
Publication statusPublished or Issued - Aug 2007
Externally publishedYes


  • BDNF (brain derived neurotrophic factor)
  • Major depressive disorder
  • Mexican-Americans
  • Pharmacogenetics
  • Polymorphism
  • Psychiatry
  • Single nucleotide polymorphism
  • Val66Met
  • rs6265

ASJC Scopus subject areas

  • Neuroscience(all)

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