The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

Miriam A Lynn, Georgina Eden, Feargal J Ryan, Julien Bensalem, Xuemin Wang, Stephen J Blake, Jocelyn M Choo, Yee Tee Chern, Anastasia Sribnaia, Jane James, Saoirse C Benson, Lauren Sandeman, Jianling Xie, Sofia Hassiotis, Emily W Sun, Alyce M Martin, Marianne D Keller, Damien J Keating, Timothy J Sargeant, Christopher G ProudSteve L Wesselingh, Geraint B Rogers, David J Lynn

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30 Citations (Scopus)


Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan because of a genetic deficiency. We investigate the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for more than 700 days in comparison with untreated control mice. We demonstrate the emergence of two different low-diversity community types, post-antibiotic microbiota (PAM) I and PAM II, following antibiotic exposure. PAM II but not PAM I mice have impaired immunity, increased insulin resistance, and evidence of increased inflammaging in later life as well as a reduced lifespan. Our data suggest that differences in the composition of the gut microbiota following antibiotic exposure differentially affect host health and longevity in later life.

Original languageEnglish
Pages (from-to)109564
JournalCell Reports
Issue number8
Publication statusPublished or Issued - 24 Aug 2021

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