The development of a plant-based vaccine for measles

D. E. Webster; M. C. Thomas; Z. Huang; S. L. Wesselingh

doi:10.1016/j.vaccine.2004.11.018

The development of a plant-based vaccine for measles

D. E. Webster, M. C. Thomas, Z. Huang, S. L. Wesselingh

Precision Cancer Medicine

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.

Original language	English
Pages (from-to)	1859-1865
Number of pages	7
Journal	Vaccine
Volume	23
Issue number	15 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.vaccine.2004.11.018
Publication status	Published or Issued - 7 Mar 2005

Keywords

Measles
Plant-derived vaccine
Prime-boost vaccination

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2004.11.018

Cite this

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title = "The development of a plant-based vaccine for measles",

abstract = "Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.",

keywords = "Measles, Plant-derived vaccine, Prime-boost vaccination",

author = "Webster, {D. E.} and Thomas, {M. C.} and Z. Huang and Wesselingh, {S. L.}",

note = "Funding Information: The authors wish to thank Michelle Cooney and Terri King for technical assistance and Dr. Ian Dry and Prof. Richard Strugnell for their ongoing support of this project. This research was funded by the National Health and Medical Research Council of Australia.",

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AU - Webster, D. E.

AU - Thomas, M. C.

AU - Huang, Z.

AU - Wesselingh, S. L.

N1 - Funding Information: The authors wish to thank Michelle Cooney and Terri King for technical assistance and Dr. Ian Dry and Prof. Richard Strugnell for their ongoing support of this project. This research was funded by the National Health and Medical Research Council of Australia.

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N2 - Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.

AB - Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.

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The development of a plant-based vaccine for measles

Abstract

Keywords

ASJC Scopus subject areas

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