The development of a plant-based vaccine for measles

D. E. Webster, M. C. Thomas, Z. Huang, S. L. Wesselingh

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.

Original languageEnglish
Pages (from-to)1859-1865
Number of pages7
JournalVaccine
Volume23
Issue number15 SPEC. ISS.
DOIs
Publication statusPublished or Issued - 7 Mar 2005
Externally publishedYes

Keywords

  • Measles
  • Plant-derived vaccine
  • Prime-boost vaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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