The effect of modifying dietary LA and ALA intakes on omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in human adults: A systematic review and commentary

K. E. Wood; E. Mantzioris; R. A. Gibson; C. E. Ramsden; B. S. Muhlhausler

doi:10.1016/j.plefa.2015.01.001

The effect of modifying dietary LA and ALA intakes on omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in human adults: A systematic review and commentary

K. E. Wood, E. Mantzioris, R. A. Gibson, C. E. Ramsden, B. S. Muhlhausler

SAHMRI Women And Kids

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

This paper presents a systematic review of human studies investigating the effect of altering dietary omega-3 polyunsaturated fatty acid (n-3 PUFA) alpha-linolenic acid (ALA) and omega-6 polyunsaturated fatty acid (n-6 PUFA) linoleic acid (LA) intakes on n-3 long-chain polyunsaturated fatty acid (LCPUFA) status in adult humans. The results suggest that it is possible to increase n-3 LCPUFA status by reducing LA and/or increasing ALA intake in humans, although decreasing LA intake to below 2.5%. E may be required to specifically increase levels of the n-3 LCPUFA docosahexaenoic acid (DHA). The majority of studies in this area to date have been relatively poor in quality, which limits the ability to draw robust conclusions, and we present a series of recommendations to improve the quality of future studies in fatty acid nutrition in humans.

Original language	English
Pages (from-to)	47-55
Number of pages	9
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	95
DOIs	https://doi.org/10.1016/j.plefa.2015.01.001
Publication status	Published or Issued - 1 Apr 2015

Keywords

ALA
DHA
Diet
EPA
Human
LA

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology

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10.1016/j.plefa.2015.01.001

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Wood, K. E., Mantzioris, E., Gibson, R. A., Ramsden, C. E., & Muhlhausler, B. S. (2015). The effect of modifying dietary LA and ALA intakes on omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in human adults: A systematic review and commentary. Prostaglandins Leukotrienes and Essential Fatty Acids, 95, 47-55. https://doi.org/10.1016/j.plefa.2015.01.001

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abstract = "This paper presents a systematic review of human studies investigating the effect of altering dietary omega-3 polyunsaturated fatty acid (n-3 PUFA) alpha-linolenic acid (ALA) and omega-6 polyunsaturated fatty acid (n-6 PUFA) linoleic acid (LA) intakes on n-3 long-chain polyunsaturated fatty acid (LCPUFA) status in adult humans. The results suggest that it is possible to increase n-3 LCPUFA status by reducing LA and/or increasing ALA intake in humans, although decreasing LA intake to below 2.5%. E may be required to specifically increase levels of the n-3 LCPUFA docosahexaenoic acid (DHA). The majority of studies in this area to date have been relatively poor in quality, which limits the ability to draw robust conclusions, and we present a series of recommendations to improve the quality of future studies in fatty acid nutrition in humans.",

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The effect of modifying dietary LA and ALA intakes on omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in human adults: A systematic review and commentary. / Wood, K. E.; Mantzioris, E.; Gibson, R. A. et al.
In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 95, 01.04.2015, p. 47-55.

Research output: Contribution to journal › Article › peer-review

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T2 - A systematic review and commentary

AU - Wood, K. E.

AU - Mantzioris, E.

AU - Gibson, R. A.

AU - Ramsden, C. E.

AU - Muhlhausler, B. S.

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AB - This paper presents a systematic review of human studies investigating the effect of altering dietary omega-3 polyunsaturated fatty acid (n-3 PUFA) alpha-linolenic acid (ALA) and omega-6 polyunsaturated fatty acid (n-6 PUFA) linoleic acid (LA) intakes on n-3 long-chain polyunsaturated fatty acid (LCPUFA) status in adult humans. The results suggest that it is possible to increase n-3 LCPUFA status by reducing LA and/or increasing ALA intake in humans, although decreasing LA intake to below 2.5%. E may be required to specifically increase levels of the n-3 LCPUFA docosahexaenoic acid (DHA). The majority of studies in this area to date have been relatively poor in quality, which limits the ability to draw robust conclusions, and we present a series of recommendations to improve the quality of future studies in fatty acid nutrition in humans.

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The effect of modifying dietary LA and ALA intakes on omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in human adults: A systematic review and commentary

Abstract

Keywords

ASJC Scopus subject areas

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