Abstract
This study showed that the antigenicity of a malarial epitope increased with the length of the epitope when inserted at positions aa26 (amino acid position 26) and aa196, but not at aa213, of the Pseudomonas aeruginosa major outer membrane protein OprF (326 amino acids). Immunization studies showed that a 19-aa epitope was significantly more immunogenic than a 7-aa epitope when inserted at aa26 of OprF, while neither an 11- nor 19-aa epitope fused to the C-terminus of glutathione S-transferase was immunogenic.
Original language | English |
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Pages (from-to) | 209-214 |
Number of pages | 6 |
Journal | FEMS Microbiology Letters |
Volume | 140 |
Issue number | 2-3 |
DOIs | |
Publication status | Published or Issued - 1 Jul 1996 |
Externally published | Yes |
Keywords
- Antigen expression
- Immune response
- Malarial epitope
- OprF
ASJC Scopus subject areas
- Microbiology
- Molecular Biology
- Genetics