The extracellular matrix in digestive cancer

Daniel L. Worthley; Andrew S. Giraud; Timothy C. Wang

doi:10.1007/s12307-010-0053-4

The extracellular matrix in digestive cancer

Daniel L. Worthley, Andrew S. Giraud, Timothy C. Wang

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The extracellular components of the cancer microenvironment play a critical role in tumor initiation, progression and invasion. In this review we examine the normal formation and function of the basement membrane and extracellular matrix. We characterize the interactions between the matrix and the epithelium and explore the causes and consequences of the extracellular remodeling that accompanies carcinogenesis. Finally, we address the therapeutic possibilities of incorporating matrix as well as epithelial strategies in the management of digestive cancer.

Original language	English
Pages (from-to)	177-185
Number of pages	9
Journal	Cancer Microenvironment
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s12307-010-0053-4
Publication status	Published or Issued - Dec 2010
Externally published	Yes

Keywords

Bone-marrow derived cells
Cancer
Cancer stroma
Digestive system neoplasms
Extracellular matrix
Gastrointestinal cancer
Neoplasms

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s12307-010-0053-4

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title = "The extracellular matrix in digestive cancer",

abstract = "The extracellular components of the cancer microenvironment play a critical role in tumor initiation, progression and invasion. In this review we examine the normal formation and function of the basement membrane and extracellular matrix. We characterize the interactions between the matrix and the epithelium and explore the causes and consequences of the extracellular remodeling that accompanies carcinogenesis. Finally, we address the therapeutic possibilities of incorporating matrix as well as epithelial strategies in the management of digestive cancer.",

keywords = "Bone-marrow derived cells, Cancer, Cancer stroma, Digestive system neoplasms, Extracellular matrix, Gastrointestinal cancer, Neoplasms",

author = "Worthley, {Daniel L.} and Giraud, {Andrew S.} and Wang, {Timothy C.}",

note = "Funding Information: Sources of support The Royal Australasian College of Physicians Cottrell Fellowship, the Queensland State Government Smart State PhD award and the NHMRC/RG Menzies fellowship (D.L.W).",

year = "2010",

month = dec,

doi = "10.1007/s12307-010-0053-4",

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T1 - The extracellular matrix in digestive cancer

AU - Worthley, Daniel L.

AU - Giraud, Andrew S.

AU - Wang, Timothy C.

N1 - Funding Information: Sources of support The Royal Australasian College of Physicians Cottrell Fellowship, the Queensland State Government Smart State PhD award and the NHMRC/RG Menzies fellowship (D.L.W).

PY - 2010/12

Y1 - 2010/12

N2 - The extracellular components of the cancer microenvironment play a critical role in tumor initiation, progression and invasion. In this review we examine the normal formation and function of the basement membrane and extracellular matrix. We characterize the interactions between the matrix and the epithelium and explore the causes and consequences of the extracellular remodeling that accompanies carcinogenesis. Finally, we address the therapeutic possibilities of incorporating matrix as well as epithelial strategies in the management of digestive cancer.

AB - The extracellular components of the cancer microenvironment play a critical role in tumor initiation, progression and invasion. In this review we examine the normal formation and function of the basement membrane and extracellular matrix. We characterize the interactions between the matrix and the epithelium and explore the causes and consequences of the extracellular remodeling that accompanies carcinogenesis. Finally, we address the therapeutic possibilities of incorporating matrix as well as epithelial strategies in the management of digestive cancer.

KW - Bone-marrow derived cells

KW - Cancer

KW - Cancer stroma

KW - Digestive system neoplasms

KW - Extracellular matrix

KW - Gastrointestinal cancer

KW - Neoplasms

UR - http://www.scopus.com/inward/record.url?scp=78649682497&partnerID=8YFLogxK

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DO - 10.1007/s12307-010-0053-4

M3 - Article

C2 - 21209783

AN - SCOPUS:78649682497

SN - 1875-2292

VL - 3

SP - 177

EP - 185

JO - Cancer Microenvironment

JF - Cancer Microenvironment

IS - 1

ER -

The extracellular matrix in digestive cancer

Abstract

Keywords

ASJC Scopus subject areas

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