The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific

Andrey N. Shkoporov; Adam G. Clooney; Thomas D.S. Sutton; Feargal J. Ryan; Karen M. Daly; James A. Nolan; Siobhan A. McDonnell; Ekaterina V. Khokhlova; Lorraine A. Draper; Amanda Forde; Emma Guerin; Vimalkumar Velayudhan; R. Paul Ross; Colin Hill

doi:10.1016/j.chom.2019.09.009

The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific

Andrey N. Shkoporov
, Adam G. Clooney
, Thomas D.S. Sutton
, Feargal J. Ryan
, Karen M. Daly
, James A. Nolan
, Siobhan A. McDonnell
, Ekaterina V. Khokhlova
, Lorraine A. Draper
, Amanda Forde
, Emma Guerin
, Vimalkumar Velayudhan
, R. Paul Ross
, Colin Hill

Research output: Contribution to journal › Article › peer-review

537 Citations (Scopus)

Abstract

Shkoporov et al. demonstrate high individual specificity and temporal stability of the human gut virome. They describe a numerically prevalent and persisting fraction of the viral community, termed persistent personal virome (PPV). The PPV consists mainly of virulent bacteriophages predicted to target major taxonomic groups of gut bacteria.

Original language	English
Pages (from-to)	527-541.e5
Journal	Cell Host and Microbe
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2019.09.009
Publication status	Published or Issued - 9 Oct 2019
Externally published	Yes

Keywords

CRISPR
Microviridae
bacteriophages
crAss-like phages
crAssphage
human microbiome
longitudinal study
persistent personal virome
phageome
virome

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2019.09.009

Cite this

Shkoporov, A. N., Clooney, A. G., Sutton, T. D. S., Ryan, F. J., Daly, K. M., Nolan, J. A., McDonnell, S. A., Khokhlova, E. V., Draper, L. A., Forde, A., Guerin, E., Velayudhan, V., Ross, R. P., & Hill, C. (2019). The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific. Cell Host and Microbe, 26(4), 527-541.e5. https://doi.org/10.1016/j.chom.2019.09.009

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abstract = "Shkoporov et al. demonstrate high individual specificity and temporal stability of the human gut virome. They describe a numerically prevalent and persisting fraction of the viral community, termed persistent personal virome (PPV). The PPV consists mainly of virulent bacteriophages predicted to target major taxonomic groups of gut bacteria.",

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AU - Shkoporov, Andrey N.

AU - Clooney, Adam G.

AU - Sutton, Thomas D.S.

AU - Ryan, Feargal J.

AU - Daly, Karen M.

AU - Nolan, James A.

AU - McDonnell, Siobhan A.

AU - Khokhlova, Ekaterina V.

AU - Draper, Lorraine A.

AU - Forde, Amanda

AU - Guerin, Emma

AU - Velayudhan, Vimalkumar

AU - Ross, R. Paul

AU - Hill, Colin

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AB - Shkoporov et al. demonstrate high individual specificity and temporal stability of the human gut virome. They describe a numerically prevalent and persisting fraction of the viral community, termed persistent personal virome (PPV). The PPV consists mainly of virulent bacteriophages predicted to target major taxonomic groups of gut bacteria.

KW - CRISPR

KW - Microviridae

KW - bacteriophages

KW - crAss-like phages

KW - crAssphage

KW - human microbiome

KW - longitudinal study

KW - persistent personal virome

KW - phageome

KW - virome

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JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific

Abstract

Keywords

ASJC Scopus subject areas

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