TY - JOUR
T1 - The impact of fetal gender and ethnicity on the risk of spontaneous preterm delivery in women with symptoms of preterm labor
AU - Wilms, Femke F.
AU - Vis, Jolande Y.
AU - Oudijk, Martijn A.
AU - Kwee, Anneke
AU - Porath, Martina M.
AU - Scheepers, Hubertina C.J.
AU - Spaanderman, Marc E.A.
AU - Bloemenkamp, Kitty W.M.
AU - Bolte, Antoinette C.
AU - Bax, Caroline J.
AU - Cornette, Jérôme M.J.
AU - Duvekot, Johannes J.
AU - Nij Bijvanck, Bas W.A.
AU - Eijck, Jim van
AU - Franssen, Maureen T.M.
AU - Sollie, Krystyna M.
AU - Vandenbussche, Frank P.H.A.
AU - Woiski, Mallory D.
AU - van der Post, Joris A.M.
AU - Bossuyt, Patrick M.M.
AU - Opmeer, Brent C.
AU - Mol, Ben W.J.
AU - van Baaren, Gert Jan
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Objective: The objective of this study is to evaluate the relation among fetal gender, ethnicity, and preterm labor (PTL) and preterm delivery (PTD). Methods: A secondary analysis was performed of a prospective cohort study including women with symptoms of PTL between 24 and 34 weeks. The proportion of women carrying a male or female fetus at the onset of PTL was calculated. Gestational age at delivery and risk of PTD of both fetal genders was compared and interaction of fetal gender and maternal ethnicity on the risk of PTD was evaluated. Results: Of the 594 included women, 327 (55%) carried a male fetus. Median gestational age at delivery in women pregnant with a male fetus was 37 5/7 (IQR 34 4/7–39 1/7) weeks compared with 38 1/7 (IQR 36 0/7–39 5/7) weeks in women pregnant with a female fetus (p = 0.032). The risk of PTD did not differ significantly. In Caucasians, we did find an increased risk of PTD before 37 weeks in women pregnant with a male fetus (OR 1.9 (95% CI 1.2–3.0)). Conclusions: The majority of women with PTL are pregnant with a male fetus and these women deliver slightly earlier. Race seems to affect this disparity.
AB - Objective: The objective of this study is to evaluate the relation among fetal gender, ethnicity, and preterm labor (PTL) and preterm delivery (PTD). Methods: A secondary analysis was performed of a prospective cohort study including women with symptoms of PTL between 24 and 34 weeks. The proportion of women carrying a male or female fetus at the onset of PTL was calculated. Gestational age at delivery and risk of PTD of both fetal genders was compared and interaction of fetal gender and maternal ethnicity on the risk of PTD was evaluated. Results: Of the 594 included women, 327 (55%) carried a male fetus. Median gestational age at delivery in women pregnant with a male fetus was 37 5/7 (IQR 34 4/7–39 1/7) weeks compared with 38 1/7 (IQR 36 0/7–39 5/7) weeks in women pregnant with a female fetus (p = 0.032). The risk of PTD did not differ significantly. In Caucasians, we did find an increased risk of PTD before 37 weeks in women pregnant with a male fetus (OR 1.9 (95% CI 1.2–3.0)). Conclusions: The majority of women with PTL are pregnant with a male fetus and these women deliver slightly earlier. Race seems to affect this disparity.
KW - Ethnicity
KW - fetal gender
KW - preterm delivery
KW - preterm labor
UR - http://www.scopus.com/inward/record.url?scp=84959050616&partnerID=8YFLogxK
U2 - 10.3109/14767058.2016.1139566
DO - 10.3109/14767058.2016.1139566
M3 - Article
C2 - 26911700
AN - SCOPUS:84959050616
SN - 1476-7058
VL - 29
SP - 3563
EP - 3569
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 21
ER -