The insulin-sensitizing role of the fat derived hormone adiponectin

Leonie Heilbronn; S. R. Smith; E. Ravussin

doi:10.2174/1381612033454766

The insulin-sensitizing role of the fat derived hormone adiponectin

Leonie Heilbronn, S. R. Smith, E. Ravussin

Research output: Contribution to journal › Review article › peer-review

72 Citations (Scopus)

Abstract

Adiponectin is an insulin-sensitizing hormone whose blood concentration is reduced in obesity and type 2 diabetes. Administration of recombinant adiponectin in rodents increases glucose uptake and increases fat oxidation in muscle, reduces fatty acid uptake and hepatic glucose production in liver, and improves whole body insulin resistance. The exact receptor and signaling systems are unknown, however, recent studies suggest adiponectin activates AMPK, a putative master metabolic regulator. Thus, excitement surrounds the potential for adiponectin, or a homologue of adiponectin, as pharamacotherapy agents for patients suffering from the metabolic syndrome and more particularly for individuals with insulin resistance and type 2 diabetes.

Original language	English
Pages (from-to)	1411-1418
Number of pages	8
Journal	Current Pharmaceutical Design
Volume	9
Issue number	17
DOIs	https://doi.org/10.2174/1381612033454766
Publication status	Published or Issued - 2003
Externally published	Yes

Keywords

Adiponectin
Fatty acid oxidation
Hepatic glucose production
Insulin sensitivity
Type 2 diabetes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.2174/1381612033454766

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abstract = "Adiponectin is an insulin-sensitizing hormone whose blood concentration is reduced in obesity and type 2 diabetes. Administration of recombinant adiponectin in rodents increases glucose uptake and increases fat oxidation in muscle, reduces fatty acid uptake and hepatic glucose production in liver, and improves whole body insulin resistance. The exact receptor and signaling systems are unknown, however, recent studies suggest adiponectin activates AMPK, a putative master metabolic regulator. Thus, excitement surrounds the potential for adiponectin, or a homologue of adiponectin, as pharamacotherapy agents for patients suffering from the metabolic syndrome and more particularly for individuals with insulin resistance and type 2 diabetes.",

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N2 - Adiponectin is an insulin-sensitizing hormone whose blood concentration is reduced in obesity and type 2 diabetes. Administration of recombinant adiponectin in rodents increases glucose uptake and increases fat oxidation in muscle, reduces fatty acid uptake and hepatic glucose production in liver, and improves whole body insulin resistance. The exact receptor and signaling systems are unknown, however, recent studies suggest adiponectin activates AMPK, a putative master metabolic regulator. Thus, excitement surrounds the potential for adiponectin, or a homologue of adiponectin, as pharamacotherapy agents for patients suffering from the metabolic syndrome and more particularly for individuals with insulin resistance and type 2 diabetes.

AB - Adiponectin is an insulin-sensitizing hormone whose blood concentration is reduced in obesity and type 2 diabetes. Administration of recombinant adiponectin in rodents increases glucose uptake and increases fat oxidation in muscle, reduces fatty acid uptake and hepatic glucose production in liver, and improves whole body insulin resistance. The exact receptor and signaling systems are unknown, however, recent studies suggest adiponectin activates AMPK, a putative master metabolic regulator. Thus, excitement surrounds the potential for adiponectin, or a homologue of adiponectin, as pharamacotherapy agents for patients suffering from the metabolic syndrome and more particularly for individuals with insulin resistance and type 2 diabetes.

KW - Adiponectin

KW - Fatty acid oxidation

KW - Hepatic glucose production

KW - Insulin sensitivity

KW - Type 2 diabetes

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The insulin-sensitizing role of the fat derived hormone adiponectin

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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