TY - JOUR
T1 - The relationship of retinal vascular calibre to diabetes and retinopathy
T2 - The Australian Diabetes, Obesity and Lifestyle (AusDiab) study
AU - Tikellis, G.
AU - Wang, J. J.
AU - Tapp, R.
AU - Simpson, R.
AU - Mitchell, P.
AU - Zimmet, P. Z.
AU - Shaw, J.
AU - Wong, T. Y.
N1 - Funding Information:
Acknowledgements This study was supported by the National Health and Medical Research Council grants 350448 and 233200, and a Sylvia and Charles Viertel Charitable Foundation grant. We are grateful to S. Murray (AusDiab project manager) and S. Fournel (AusDiab administration) for their invaluable contribution to the study. We would also like to thank M. Dalton (AusDiab field coordinator 1999–2000), T. Whalen and A. Bonney (AusDiab field coordinators 2004–2005), all the AusDiab support staff, and especially the participants for volunteering their time to be involved in the study.
PY - 2007/11
Y1 - 2007/11
N2 - Aims/hypothesis: The aim of the study was to examine the relationship of retinal vascular calibre with glucose intolerance, diabetes and retinopathy in a population-based cohort. Methods: The Australian Diabetes, Obesity and Lifestyle study recruited adults aged ≥25 years old from across Australia. Participants were classified using an oral glucose tolerance test as having normal glucose tolerance (NGT), impaired glucose tolerance (IGT), impaired fasting glucose (IFG), known diabetes or newly diagnosed diabetes. Digital retinal photographs were taken of all participants with diabetes, IGT and IFG, and a sample of those with NGT, and graded for the presence of retinopathy. Retinal vascular calibre was measured from photographs by a computer-assisted method. Results: Of the 1,998 participants with gradable retinal images, 16% had known diabetes, 17% newly diagnosed diabetes, 42% IGT, 6% IFG and 19% NGT. After multivariable adjustment, retinal arteriolar calibre was significantly larger in people with known diabetes (178.9 μm) compared with participants with NGT (174.6 μm, p = 0.02), IGT/IFG (175.5 μm, p = 0.02) or newly diagnosed diabetes (175.6 μm, p = 0.047). One SD increase in mean arteriolar calibre was associated with higher odds of diabetes compared with NGT (odds ratio [OR] = 1.28, 95%CI = 1.06-1.55). After multivariable adjustment, each SD increase in venular calibre was associated with higher odds of having retinopathy in persons with IGT/IFG (OR = 1.78, 95%CI = 1.36-2.34) or in persons with diabetes (OR = 1.68, 95%CI = 1.23-2.29). Conclusions/interpretation: Diabetes is associated with larger retinal arteriolar calibre and retinopathy with larger retinal venular calibre. The contrasting associations may reflect different underlying pathophysiological processes in the natural history of diabetes.
AB - Aims/hypothesis: The aim of the study was to examine the relationship of retinal vascular calibre with glucose intolerance, diabetes and retinopathy in a population-based cohort. Methods: The Australian Diabetes, Obesity and Lifestyle study recruited adults aged ≥25 years old from across Australia. Participants were classified using an oral glucose tolerance test as having normal glucose tolerance (NGT), impaired glucose tolerance (IGT), impaired fasting glucose (IFG), known diabetes or newly diagnosed diabetes. Digital retinal photographs were taken of all participants with diabetes, IGT and IFG, and a sample of those with NGT, and graded for the presence of retinopathy. Retinal vascular calibre was measured from photographs by a computer-assisted method. Results: Of the 1,998 participants with gradable retinal images, 16% had known diabetes, 17% newly diagnosed diabetes, 42% IGT, 6% IFG and 19% NGT. After multivariable adjustment, retinal arteriolar calibre was significantly larger in people with known diabetes (178.9 μm) compared with participants with NGT (174.6 μm, p = 0.02), IGT/IFG (175.5 μm, p = 0.02) or newly diagnosed diabetes (175.6 μm, p = 0.047). One SD increase in mean arteriolar calibre was associated with higher odds of diabetes compared with NGT (odds ratio [OR] = 1.28, 95%CI = 1.06-1.55). After multivariable adjustment, each SD increase in venular calibre was associated with higher odds of having retinopathy in persons with IGT/IFG (OR = 1.78, 95%CI = 1.36-2.34) or in persons with diabetes (OR = 1.68, 95%CI = 1.23-2.29). Conclusions/interpretation: Diabetes is associated with larger retinal arteriolar calibre and retinopathy with larger retinal venular calibre. The contrasting associations may reflect different underlying pathophysiological processes in the natural history of diabetes.
KW - Diabetes mellitus
KW - Impaired fasting glucose
KW - Impaired glucose tolerance
KW - Retinal arteriolar calibre
KW - Retinal venular calibre
KW - Retinopathy
UR - http://www.scopus.com/inward/record.url?scp=34848844432&partnerID=8YFLogxK
U2 - 10.1007/s00125-007-0822-x
DO - 10.1007/s00125-007-0822-x
M3 - Article
C2 - 17891374
AN - SCOPUS:34848844432
SN - 0012-186X
VL - 50
SP - 2263
EP - 2271
JO - Diabetologia
JF - Diabetologia
IS - 11
ER -