The role of Eph/ephrin molecules in stromal–hematopoietic interactions

Thao M. Nguyen; Agnieszka Arthur; Stan Gronthos

doi:10.1007/s12185-015-1886-x

The role of Eph/ephrin molecules in stromal–hematopoietic interactions

Thao M. Nguyen, Agnieszka Arthur, Stan Gronthos

Blood Cancer Program

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

Bone marrow mesenchymal stromal/stem cells (BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrin ligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrin-targeted therapeutic strategies that are currently being pursued for various hematotological malignancies.

Original language	English
Pages (from-to)	145-154
Number of pages	10
Journal	International Journal of Hematology
Volume	103
Issue number	2
DOIs	https://doi.org/10.1007/s12185-015-1886-x
Publication status	Published or Issued - 1 Feb 2016

Keywords

Bone marrow mesenchymal/stem cells
Eph receptors
Ephrin ligands
Haematopoietic stem cells niche
Stromal cells

ASJC Scopus subject areas

Hematology

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10.1007/s12185-015-1886-x

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abstract = "Bone marrow mesenchymal stromal/stem cells (BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrin ligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrin-targeted therapeutic strategies that are currently being pursued for various hematotological malignancies.",

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AU - Arthur, Agnieszka

AU - Gronthos, Stan

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AB - Bone marrow mesenchymal stromal/stem cells (BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrin ligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrin-targeted therapeutic strategies that are currently being pursued for various hematotological malignancies.

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KW - Ephrin ligands

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The role of Eph/ephrin molecules in stromal–hematopoietic interactions

Abstract

Keywords

ASJC Scopus subject areas

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