TY - JOUR
T1 - The role of intracoronary imaging in translational research
AU - Montarello, Nicholas J.
AU - Nelson, Adam J.
AU - Verjans, Johan
AU - Nicholls, Stephen J.
AU - Psaltis, Peter J.
N1 - Funding Information:
The authors thank Mr. Giuseppe DiGiovanni from the Atherosclerotic Imaging Core Laboratory, South Australian Health and Medical Research Institute for assistance with image preparation. Funding: AJN receives personal funding from the National Heart Foundation and the Royal Australian College of Physicians. SJN receives a Principal Research Fellowship from the National Health and Medical Research Council (NHMRC) of Australia (ID1111630). PJP receives a L2 Future Leader Fellowship from the National Heart Foundation of Australia (FLF102056) and L2 Career Development Fellowship from the NHMRC (CDF1161506).
Funding Information:
ICMJE uniform disclosure forms (available at http:// dx.doi.org/10.21037/cdt-20-1). The series “Intracoronary Imaging” was commissioned by the editorial office without any funding or sponsorship. SJN reports grants from AstraZeneca, Amgen, Anthera, Eli Lilly, Esperion, Novartis, Cerenis, The Medicines Company, Resverlogix, InfraReDx, Roche, Sanofi-Regeneron and LipoScience, personal fees from AstraZeneca, Akcea, Eli Lilly, Anthera, Omthera, Merck, Takeda, Resverlogix, Sanofi-Regeneron, CSL Behring, Esperion, Boehringer Ingelheim, outside the submitted work. In addition, SJN has a patent as a named inventor on a patent for the use of PCSK9 inhibitors and their impact on atherosclerotic plaque, Issued. PJP reports personal fees from ESPERION Therapeutics, Bayer, Boehringer Ingelheim, Merck, Pfizer, Astra Zeneca, grants from ABBOTT Vascular, outside the submitted work. SJN serves as an unpaid editorial board member of Cardiovascular Diagnosis and Therapy from Jul 2019 to Jun 2021. PJP serves as an unpaid editorial board member of Cardiovascular Diagnosis and Therapy from Aug 2019 to Jul 2021. The
PY - 2020/10
Y1 - 2020/10
N2 - Atherosclerotic cardiovascular disease is a key public health concern worldwide and leading cause of morbidity, mortality and health economic costs. Understanding atherosclerotic plaque microstructure in relation to molecular mechanisms that underpin its initiation and progression is needed to provide the best chance of combating this disease. Evolving vessel wall-based, endovascular coronary imaging modalities, including intravascular ultrasound (IVUS), optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS), used in isolation or as hybrid modalities, have been advanced to allow comprehensive visualization of the pathological substrate of coronary atherosclerosis and accurately measure temporal changes in both the vessel wall and plaque characteristics. This has helped further our appreciation of the natural history of coronary artery disease (CAD) and the risk for major adverse cardiovascular events (MACE), evaluate the responsiveness to conventional and experimental therapeutic interventions, and assist in guiding percutaneous coronary intervention (PCI). Here we review the use of different imaging modalities for these purposes and the lessons they have provided thus far.
AB - Atherosclerotic cardiovascular disease is a key public health concern worldwide and leading cause of morbidity, mortality and health economic costs. Understanding atherosclerotic plaque microstructure in relation to molecular mechanisms that underpin its initiation and progression is needed to provide the best chance of combating this disease. Evolving vessel wall-based, endovascular coronary imaging modalities, including intravascular ultrasound (IVUS), optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS), used in isolation or as hybrid modalities, have been advanced to allow comprehensive visualization of the pathological substrate of coronary atherosclerosis and accurately measure temporal changes in both the vessel wall and plaque characteristics. This has helped further our appreciation of the natural history of coronary artery disease (CAD) and the risk for major adverse cardiovascular events (MACE), evaluate the responsiveness to conventional and experimental therapeutic interventions, and assist in guiding percutaneous coronary intervention (PCI). Here we review the use of different imaging modalities for these purposes and the lessons they have provided thus far.
KW - Coronary artery disease (CAD)
KW - Intracoronary imaging
KW - Intravascular ultrasound (IVUS)
KW - Near-infrared spectroscopy (NIRS)
KW - Optical coherence tomography (OCT)
KW - Plaque imaging
UR - http://www.scopus.com/inward/record.url?scp=85094954878&partnerID=8YFLogxK
U2 - 10.21037/cdt-20-1
DO - 10.21037/cdt-20-1
M3 - Review article
C2 - 33224769
AN - SCOPUS:85094954878
VL - 10
SP - 1480
EP - 1507
JO - Cardiovascular Diagnosis and Therapy
JF - Cardiovascular Diagnosis and Therapy
SN - 2223-3652
IS - 5
ER -