The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: Implications in the development of type-2 diabetes

Jianling Xie, Terence P. Herbert

Research output: Contribution to journalReview articlepeer-review

52 Citations (Scopus)


Type-2 diabetes mellitus (T2DM) is a disorder that is characterized by high blood glucose concentration in the context of insulin resistance and/or relative insulin deficiency. It causes metabolic changes that lead to the damage and functional impairment of organs and tissues resulting in increased morbidity and mortality. It is this form of diabetes whose prevalence is increasing at an alarming rate due to the 'obesity epidemic', as obesity is a key risk factor in the development of insulin resistance. However, the majority of individuals who have insulin resistance do not develop diabetes due to a compensatory increase in insulin secretion in response to an increase in insulin demand. This adaptive response is sustained by an increase in both β-cell function and mass. Importantly, there is increasing evidence that the Serine/Threonine kinase mammalian target of rapamycin (mTOR) plays a key role in the regulation of β-cell mass and therefore likely plays a critical role in β-cell adaptation. Therefore, the primary focus of this review is to summarize our current understanding of the role of mTOR in stimulating pancreatic β-cell mass and thus, in the prevention of type-2 diabetes.

Original languageEnglish
Pages (from-to)1289-1304
Number of pages16
JournalCellular and Molecular Life Sciences
Issue number8
Publication statusPublished or Issued - Apr 2012
Externally publishedYes


  • AMPK
  • Obesity
  • PKB
  • Rheb
  • S6K
  • TSC
  • Type 2 diabetes
  • mTOR
  • β-Cell mass

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this