@inbook{ff82d91f27ae40efbdd79c64eaaa446d,
title = "The Role of Vitamin D in Anemia",
abstract = "Vitamin D may increase the risk, especially when inflammation is present. Vitamin D appears to increase the amount of iron available for red blood cell synthesis by reducing hepatic hepcidin synthesis, a hormone that binds to ferroportin and blocks cellular iron export. An association between serum 25-hydroxyvitamin D (25OHD), a biomarker of vitamin D status, and hemoglobin concentration has been reported in several studies. The association is weak and is modified by sex, ethnicity, and background rates of inflammation and anemia. Moreover, the association between 25OHD and hemoglobin is not continuous with a threshold effect at approximately 50 nmol/L, above which higher 25OHD is no longer associated with hemoglobin. Randomized control trials do not support vitamin D supplementation to reduce anemia. Studies have been small and in heterogenous groups, with including participants without anemia or inflammation. Larger, well-powered trials are needed ideally in participants with a high baseline burden of inflammation and anemia and low 25OHD.",
keywords = "25hydroxyvitamin D, Anemia, Hepcidin, Inflammation, Iron, Observational studies, Randomized control trials, Vitamin D",
author = "Merryn Netting and Best, \{Karen P\} and Tim Green",
note = "Publisher Copyright: {\textcopyright} Springer Nature Switzerland AG 2022.",
year = "2022",
month = dec,
day = "16",
doi = "10.1007/978-3-031-14521-6\_15",
language = "English",
isbn = "978-3-031-14520-9",
series = "Nutrition and Health",
publisher = "Springer",
pages = "195--204",
editor = "Crystal Karakochuk and Zimmermann, \{Michael B.\} and Moretti, \{Diego \} and Kraemer, \{Klaus \}",
booktitle = "Nutritional Anemia.",
}