The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation

Kimberly N. Smitheman; Tesa M. Severson; Satyajit R. Rajapurkar; Michael T. McCabe; Natalie Karpinich; James Foley; Melissa B. Pappalardi; Ashley Hughes; Wendy Halsey; Elizabeth Thomas; Christopher Traini; Kelly E. Federowicz; Jenny Laraio; Fredrick Mobegi; Geraldine Ferron-Brady; Rabinder K. Prinjha; Christopher L. Carpenter; Ryan G. Kruger; Lodewyk Wessels; Helai P. Mohammad; Daniel J. Hodson; Michael Screen; Martin Turner; Andreas Greinacher; Julia J.M. Eekels; Mitchell S. Cairo; Auke Beishuizen; Yaya Chu; Aliza Gardenswartz; Amanda M. Termuhlen; Mitchell S. Cairo; M. Frenquelli; N. Caridi; E. Antonini; F. Storti; V. Viganò; M. Gaviraghi; M. Occhionorelli; S. Bianchessi; L. Bongiovanni; A. Spinelli; M. Marcatti; D. Belloni; E. Ferrero; S. Karki; P. Brambilla; F. Martinelli-Boneschi; S. Colla; M. Ponzoni; R. A. DePinho; G. Tonon; Elena Armenteros-Monterroso; Lu Zhao; Luca Gasparoli; Tony Brooks; Kerra Pearce; Marc R. Mansour; Joost H. A. Martens; Jasper de Boer; Owen Williams; Sophia Adamia; Ivane Abiatari; Samir B. Amin; Mariateresa Fulciniti; Stephane Minvielle; Cheng Li; Philippe Moreau; Herve Avet-Loiseau; Nikhil C. Munshi; Kenneth C. Anderson; Linus Angenendt; Eike Bormann; Caroline Pabst; Vijay Alla; Dennis Görlich; Leonie Braun; Kim Dohlich; Christian Schwöppe; Stefan K Bohlander; Maria Francisca; Arteaga Klaus; Wolfgang Hartmann; Adrian Angenendt; Torsten Kessler; Rolf M Mesters; Matthias Stelljes; Bob Löwenberg; Hubert Serve; Carsten Müller-tidow Georg; Lenz Bernhard; M Christina Sauerland; Wolfgang Hiddemann; Wolfgang E Berdel; Utz Krug; Klaus H Metzeler; Jan-henrik Mikesch Tobias Herold; Christoph Schliemann; Tobias Herold; Ayalew Tefferi; Paola Guglielmelli

The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation

Kimberly N. Smitheman, Tesa M. Severson, Satyajit R. Rajapurkar, Michael T. McCabe, Natalie Karpinich, James Foley, Melissa B. Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E. Federowicz, Jenny Laraio, Fredrick Mobegi, Geraldine Ferron-Brady, Rabinder K. Prinjha, Christopher L. Carpenter, Ryan G. Kruger, Lodewyk Wessels, Helai P. MohammadDaniel J. Hodson, Michael Screen, Martin Turner, Andreas Greinacher, Julia J.M. Eekels, Mitchell S. Cairo, Auke Beishuizen, Yaya Chu, Aliza Gardenswartz, Amanda M. Termuhlen, Mitchell S. Cairo, M. Frenquelli, N. Caridi, E. Antonini, F. Storti, V. Viganò, M. Gaviraghi, M. Occhionorelli, S. Bianchessi, L. Bongiovanni, A. Spinelli, M. Marcatti, D. Belloni, E. Ferrero, S. Karki, P. Brambilla, F. Martinelli-Boneschi, S. Colla, M. Ponzoni, R. A. DePinho, G. Tonon, Elena Armenteros-Monterroso, Lu Zhao, Luca Gasparoli, Tony Brooks, Kerra Pearce, Marc R. Mansour, Joost H. A. Martens, Jasper de Boer, Owen Williams, Sophia Adamia, Ivane Abiatari, Samir B. Amin, Mariateresa Fulciniti, Stephane Minvielle, Cheng Li, Philippe Moreau, Herve Avet-Loiseau, Nikhil C. Munshi, Kenneth C. Anderson, Linus Angenendt, Eike Bormann, Caroline Pabst, Vijay Alla, Dennis Görlich, Leonie Braun, Kim Dohlich, Christian Schwöppe, Stefan K Bohlander, Maria Francisca, Arteaga Klaus, Wolfgang Hartmann, Adrian Angenendt, Torsten Kessler, Rolf M Mesters, Matthias Stelljes, Bob Löwenberg, Hubert Serve, Carsten Müller-tidow Georg, Lenz Bernhard, M Christina Sauerland, Wolfgang Hiddemann, Wolfgang E Berdel, Utz Krug, Klaus H Metzeler, Jan-henrik Mikesch Tobias Herold, Christoph Schliemann, Tobias Herold, Ayalew Tefferi, Paola Guglielmelli

Microbiome And Host Health

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Molecular causes of many inherited platelet disorders have been unraveled. Next generation sequencing facilitates diagnosis in 30-50% of patients. However, interpretation of genetic variants is challenging and requires careful evaluation in the context of the patient's phenotype. Before detailed testing is initiated, the treating physician and the patient should be aware why testing is performed and should agree on the consequences it may have, especially before testing for variants in genes associated with an increased risk for hematologic malignancies.

Original language	English
Pages (from-to)	1021-1042
Number of pages	22
Journal	Leukemia
Publication status	Published or Issued - Feb 2019

Keywords

B-cell non-Hodgkin lymphoma
Childhood
IL-15 superagonist
adolescent
cellular immunotherapy
chimeric antigen receptor
current perspectives
non-Hodgkin lymphoma
stem cell transplantation
young adult

Cite this

Smitheman, K. N., Severson, T. M., Rajapurkar, S. R., McCabe, M. T., Karpinich, N., Foley, J., Pappalardi, M. B., Hughes, A., Halsey, W., Thomas, E., Traini, C., Federowicz, K. E., Laraio, J., Mobegi, F., Ferron-Brady, G., Prinjha, R. K., Carpenter, C. L., Kruger, R. G., Wessels, L., ... Guglielmelli, P. (2019). The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation. Leukemia, 1021-1042.

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title = "The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation",

abstract = "Molecular causes of many inherited platelet disorders have been unraveled. Next generation sequencing facilitates diagnosis in 30-50% of patients. However, interpretation of genetic variants is challenging and requires careful evaluation in the context of the patient's phenotype. Before detailed testing is initiated, the treating physician and the patient should be aware why testing is performed and should agree on the consequences it may have, especially before testing for variants in genes associated with an increased risk for hematologic malignancies.",

keywords = "B-cell non-Hodgkin lymphoma, Childhood, IL-15 superagonist, adolescent, cellular immunotherapy, chimeric antigen receptor, current perspectives, non-Hodgkin lymphoma, stem cell transplantation, young adult",

author = "Smitheman, {Kimberly N.} and Severson, {Tesa M.} and Rajapurkar, {Satyajit R.} and McCabe, {Michael T.} and Natalie Karpinich and James Foley and Pappalardi, {Melissa B.} and Ashley Hughes and Wendy Halsey and Elizabeth Thomas and Christopher Traini and Federowicz, {Kelly E.} and Jenny Laraio and Fredrick Mobegi and Geraldine Ferron-Brady and Prinjha, {Rabinder K.} and Carpenter, {Christopher L.} and Kruger, {Ryan G.} and Lodewyk Wessels and Mohammad, {Helai P.} and Hodson, {Daniel J.} and Michael Screen and Martin Turner and Andreas Greinacher and Eekels, {Julia J.M.} and Cairo, {Mitchell S.} and Auke Beishuizen and Yaya Chu and Aliza Gardenswartz and Termuhlen, {Amanda M.} and Cairo, {Mitchell S.} and M. Frenquelli and N. Caridi and E. Antonini and F. Storti and V. Vigan{\`o} and M. Gaviraghi and M. Occhionorelli and S. Bianchessi and L. Bongiovanni and A. Spinelli and M. Marcatti and D. Belloni and E. Ferrero and S. Karki and P. Brambilla and F. Martinelli-Boneschi and S. Colla and M. Ponzoni and DePinho, {R. A.} and G. Tonon and Elena Armenteros-Monterroso and Lu Zhao and Luca Gasparoli and Tony Brooks and Kerra Pearce and Mansour, {Marc R.} and Martens, {Joost H. A.} and {de Boer}, Jasper and Owen Williams and Sophia Adamia and Ivane Abiatari and Amin, {Samir B.} and Mariateresa Fulciniti and Stephane Minvielle and Cheng Li and Philippe Moreau and Herve Avet-Loiseau and Munshi, {Nikhil C.} and Anderson, {Kenneth C.} and Linus Angenendt and Eike Bormann and Caroline Pabst and Vijay Alla and Dennis G{\"o}rlich and Leonie Braun and Kim Dohlich and Christian Schw{\"o}ppe and Bohlander, {Stefan K} and Maria Francisca and Arteaga Klaus and Wolfgang Hartmann and Adrian Angenendt and Torsten Kessler and Mesters, {Rolf M} and Matthias Stelljes and Bob L{\"o}wenberg and Hubert Serve and Georg, {Carsten M{\"u}ller-tidow} and Lenz Bernhard and Sauerland, {M Christina} and Wolfgang Hiddemann and Berdel, {Wolfgang E} and Utz Krug and Metzeler, {Klaus H} and Herold, {Jan-henrik Mikesch Tobias} and Christoph Schliemann and Tobias Herold and Ayalew Tefferi and Paola Guglielmelli",

year = "2019",

month = feb,

language = "English",

pages = "1021--1042",

journal = "Leukemia",

issn = "1476-5551",

publisher = "Springer Nature",

}

Smitheman, KN, Severson, TM, Rajapurkar, SR, McCabe, MT, Karpinich, N, Foley, J, Pappalardi, MB, Hughes, A, Halsey, W, Thomas, E, Traini, C, Federowicz, KE, Laraio, J, Mobegi, F, Ferron-Brady, G, Prinjha, RK, Carpenter, CL, Kruger, RG, Wessels, L, Mohammad, HP, Hodson, DJ, Screen, M, Turner, M, Greinacher, A, Eekels, JJM, Cairo, MS, Beishuizen, A, Chu, Y, Gardenswartz, A, Termuhlen, AM, Cairo, MS, Frenquelli, M, Caridi, N, Antonini, E, Storti, F, Viganò, V, Gaviraghi, M, Occhionorelli, M, Bianchessi, S, Bongiovanni, L, Spinelli, A, Marcatti, M, Belloni, D, Ferrero, E, Karki, S, Brambilla, P, Martinelli-Boneschi, F, Colla, S, Ponzoni, M, DePinho, RA, Tonon, G, Armenteros-Monterroso, E, Zhao, L, Gasparoli, L, Brooks, T, Pearce, K, Mansour, MR, Martens, JHA, de Boer, J, Williams, O, Adamia, S, Abiatari, I, Amin, SB, Fulciniti, M, Minvielle, S, Li, C, Moreau, P, Avet-Loiseau, H, Munshi, NC, Anderson, KC, Angenendt, L, Bormann, E, Pabst, C, Alla, V, Görlich, D, Braun, L, Dohlich, K, Schwöppe, C, Bohlander, SK, Francisca, M, Klaus, A, Hartmann, W, Angenendt, A, Kessler, T, Mesters, RM, Stelljes, M, Löwenberg, B, Serve, H, Georg, CM, Bernhard, L, Sauerland, MC, Hiddemann, W, Berdel, WE, Krug, U, Metzeler, KH, Herold, JMT, Schliemann, C, Herold, T, Tefferi, A & Guglielmelli, P 2019, 'The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation', Leukemia, pp. 1021-1042.

TY - JOUR

T1 - The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation

AU - Smitheman, Kimberly N.

AU - Severson, Tesa M.

AU - Rajapurkar, Satyajit R.

AU - McCabe, Michael T.

AU - Karpinich, Natalie

AU - Foley, James

AU - Pappalardi, Melissa B.

AU - Hughes, Ashley

AU - Halsey, Wendy

AU - Thomas, Elizabeth

AU - Traini, Christopher

AU - Federowicz, Kelly E.

AU - Laraio, Jenny

AU - Mobegi, Fredrick

AU - Ferron-Brady, Geraldine

AU - Prinjha, Rabinder K.

AU - Carpenter, Christopher L.

AU - Kruger, Ryan G.

AU - Wessels, Lodewyk

AU - Mohammad, Helai P.

AU - Hodson, Daniel J.

AU - Screen, Michael

AU - Turner, Martin

AU - Greinacher, Andreas

AU - Eekels, Julia J.M.

AU - Cairo, Mitchell S.

AU - Beishuizen, Auke

AU - Chu, Yaya

AU - Gardenswartz, Aliza

AU - Termuhlen, Amanda M.

AU - Cairo, Mitchell S.

AU - Frenquelli, M.

AU - Caridi, N.

AU - Antonini, E.

AU - Storti, F.

AU - Viganò, V.

AU - Gaviraghi, M.

AU - Occhionorelli, M.

AU - Bianchessi, S.

AU - Bongiovanni, L.

AU - Spinelli, A.

AU - Marcatti, M.

AU - Belloni, D.

AU - Ferrero, E.

AU - Karki, S.

AU - Brambilla, P.

AU - Martinelli-Boneschi, F.

AU - Colla, S.

AU - Ponzoni, M.

AU - DePinho, R. A.

AU - Tonon, G.

AU - Armenteros-Monterroso, Elena

AU - Zhao, Lu

AU - Gasparoli, Luca

AU - Brooks, Tony

AU - Pearce, Kerra

AU - Mansour, Marc R.

AU - Martens, Joost H. A.

AU - de Boer, Jasper

AU - Williams, Owen

AU - Adamia, Sophia

AU - Abiatari, Ivane

AU - Amin, Samir B.

AU - Fulciniti, Mariateresa

AU - Minvielle, Stephane

AU - Li, Cheng

AU - Moreau, Philippe

AU - Avet-Loiseau, Herve

AU - Munshi, Nikhil C.

AU - Anderson, Kenneth C.

AU - Angenendt, Linus

AU - Bormann, Eike

AU - Pabst, Caroline

AU - Alla, Vijay

AU - Görlich, Dennis

AU - Braun, Leonie

AU - Dohlich, Kim

AU - Schwöppe, Christian

AU - Bohlander, Stefan K

AU - Francisca, Maria

AU - Klaus, Arteaga

AU - Hartmann, Wolfgang

AU - Angenendt, Adrian

AU - Kessler, Torsten

AU - Mesters, Rolf M

AU - Stelljes, Matthias

AU - Löwenberg, Bob

AU - Serve, Hubert

AU - Georg, Carsten Müller-tidow

AU - Bernhard, Lenz

AU - Sauerland, M Christina

AU - Hiddemann, Wolfgang

AU - Berdel, Wolfgang E

AU - Krug, Utz

AU - Metzeler, Klaus H

AU - Herold, Jan-henrik Mikesch Tobias

AU - Schliemann, Christoph

AU - Herold, Tobias

AU - Tefferi, Ayalew

AU - Guglielmelli, Paola

PY - 2019/2

Y1 - 2019/2

N2 - Molecular causes of many inherited platelet disorders have been unraveled. Next generation sequencing facilitates diagnosis in 30-50% of patients. However, interpretation of genetic variants is challenging and requires careful evaluation in the context of the patient's phenotype. Before detailed testing is initiated, the treating physician and the patient should be aware why testing is performed and should agree on the consequences it may have, especially before testing for variants in genes associated with an increased risk for hematologic malignancies.

AB - Molecular causes of many inherited platelet disorders have been unraveled. Next generation sequencing facilitates diagnosis in 30-50% of patients. However, interpretation of genetic variants is challenging and requires careful evaluation in the context of the patient's phenotype. Before detailed testing is initiated, the treating physician and the patient should be aware why testing is performed and should agree on the consequences it may have, especially before testing for variants in genes associated with an increased risk for hematologic malignancies.

KW - B-cell non-Hodgkin lymphoma

KW - Childhood

KW - IL-15 superagonist

KW - adolescent

KW - cellular immunotherapy

KW - chimeric antigen receptor

KW - current perspectives

KW - non-Hodgkin lymphoma

KW - stem cell transplantation

KW - young adult

UR - http://www.mendeley.com/research/wnt-receptor-ror2-drives-interaction-multiple-myeloma-cells-microenvironment-through-akt-activation-1

M3 - Article

SN - 1476-5551

SP - 1021

EP - 1042

JO - Leukemia

JF - Leukemia

ER -

The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation

Abstract

Keywords

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