Therapeutic potential of HDPs as immunomodulatory agents.

Håvard Jenssen, Robert E.W. Hancock

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

One of the most significant advances in medical history is the discovery and development of antibiotics, which in the middle of last century was flourishing and appeared to be the ultimate solution to the treatment of life-threatening human bacterial diseases. However, lately there has been a huge decline in the rate of discovery of new antimicrobial intervention strategies in parallel with an increasing incidence of multidrug-resistant pathogens; if these circumstances do not change we will continue to approach the end of the antibiotic era. Facing this dark future, scientists are considering new strategies for intervention tailored around the appropriate (selective) stimulation of the host's immune system, and particularly rapid acting innate immunity, as an alternative to direct targeting of microbial pathogens. One recent player in such an immunomodulatory strategy is the naturally occurring host defence peptides (HDP) and their synthetic innate defence regulator (IDR) analogues. In this chapter, we will discuss the potential therapeutic use of HDPs and IDRs as immunomodulatory agents.

Original languageEnglish
Pages (from-to)329-347
Number of pages19
JournalMethods in molecular biology (Clifton, N.J.)
Volume618
DOIs
Publication statusPublished or Issued - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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