TRPs as mechanosensitive channels

Greg Barritt; Grigori Rychkov

doi:10.1038/ncb0205-105

TRPs as mechanosensitive channels

Greg Barritt, Grigori Rychkov

Research output: Contribution to journal › Comment/debate › peer-review

40 Citations (Scopus)

Abstract

Mechanosensitive channels are essential for effective cellular function, but elucidation of their molecular identity and mechanisms of activation has proven difficult. Two recent studies now implicate members of the transient receptor potential (TRP) family as components of the mechanosensitive channels in vertebrate hair cells (TRPA1) and stretch-activated channels (TRPC1) in several different vertebrate cell types.

Original language	English
Pages (from-to)	105-107
Number of pages	3
Journal	Nature Cell Biology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1038/ncb0205-105
Publication status	Published or Issued - Feb 2005
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb0205-105

Cite this

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title = "TRPs as mechanosensitive channels",

abstract = "Mechanosensitive channels are essential for effective cellular function, but elucidation of their molecular identity and mechanisms of activation has proven difficult. Two recent studies now implicate members of the transient receptor potential (TRP) family as components of the mechanosensitive channels in vertebrate hair cells (TRPA1) and stretch-activated channels (TRPC1) in several different vertebrate cell types.",

author = "Greg Barritt and Grigori Rychkov",

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AB - Mechanosensitive channels are essential for effective cellular function, but elucidation of their molecular identity and mechanisms of activation has proven difficult. Two recent studies now implicate members of the transient receptor potential (TRP) family as components of the mechanosensitive channels in vertebrate hair cells (TRPA1) and stretch-activated channels (TRPC1) in several different vertebrate cell types.

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DO - 10.1038/ncb0205-105

M3 - Comment/debate

C2 - 15689975

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SN - 1465-7392

VL - 7

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EP - 107

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 2

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TRPs as mechanosensitive channels

Abstract

ASJC Scopus subject areas

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