Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK–eIF4E Axis

Clive R. Bramham, Kirk B. Jensen, Christopher G. Proud

Research output: Contribution to journalReview articlepeer-review

79 Citations (Scopus)


The eukaryotic translation initiation factor (eIF) 4E, which binds to the 5’-cap of mRNA, undergoes phosphorylation on a single conserved serine, executed by the mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs). However, the functional consequences and physiological roles of MNK signalling have remained obscure. Now, new pharmacological and genetic tools have provided unprecedented insights into the function of MNKs and eIF4E phosphorylation. The studies suggest that MNKs control the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, cytoplasmic fragile-X protein-interacting protein 1 (CYFIP1). These recent breakthroughs go a long way to resolving the longstanding enigma and controversy surrounding the function of the MNK–eIF4E axis in cancer cell biology and neurobiology.

Original languageEnglish
Pages (from-to)847-858
Number of pages12
JournalTrends in Biochemical Sciences
Issue number10
Publication statusPublished or Issued - 1 Oct 2016


  • Autism spectrum disorders.
  • MAP kinase-interacting kinase
  • cytoplasmic fragile-X mental retardation protein
  • epithelial-mesenchymal transition
  • long-term synaptic plasticity
  • protein synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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