Two-step radiosynthesis of [18F]N-succinimidyl-4-fluorobenzoate ([18F]SFB)

Matthias Glaser, Erik Årstad, Sajinder K. Luthra, Edward G. Robins

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33 Citations (Scopus)


The acylation reagent [18F]N-succinimidyl-4-fluorobenzoate (18F-SFB) has been prepared using a new two-step approach. The starting material p-[18F]fluorobenzaldehyde (18F-FBA) was obtained by an improved radiosynthesis with a decay-corrected radiochemical yield of 66±6 % (n = 3). Reaction of 18F-FBA with (diacetoxyiodine)benzene and N-hydroxysuccinimide and preparative HPLC purification furnished 18F-SFB in an r.c.y. of 49±6 % (n = 3), based on the starting radioactivity of 18F-FBA. The radiochemical purity of 18F-SFB was >99%. Alternatively, purification by solid phase extraction gave 18F-SFB with an r.c.y. of 77±9% (n = 4) and a radiochemical purity of 89±5% (n = 4). This radiochemical synthesis only used non-aqueous solvents, which simplifies the method and facilitates subsequent applications of 18F-SFB.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number8
Publication statusPublished or Issued - 30 Jun 2009
Externally publishedYes


  • Fluorine-18
  • Fluorobenzaldehyde
  • Microwave
  • N-succinimidyl 4-fluorobenzoate
  • PET

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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