Type 2 diabetes is associated with more advanced coronary atherosclerosis on multislice computed tomography and virtual histology intravascular ultrasound

Gabija Pundziute, Joanne D. Schuijf, J. Wouter Jukema, Jacob M. van Werkhoven, Gaetano Nucifora, Isabel Decramer, Giovanna Sarno, Piet K. Vanhoenacker, Johannes H.C. Reiber, William Wijns, Jeroen J. Bax

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31 Citations (Scopus)


Background: Data on coronary plaque observations on multi-slice computed tomography (MSCT) in patients with type 2 diabetes are scarce. Methods and Results: In total, 60 patients (19 with diabetes) underwent 64-slice MSCT, followed by conventional coronary angiography with intravascular ultrasound (IVUS). Non-invasively, the extent of coronary atherosclerosis and 3 plaque types (non-calcified, calcified, mixed) were visually evaluated on MSCT. Invasively, plaque burden was assessed on gray-scale IVUS. Plaque composition was evaluated on virtual histology intravascular ultrasound (VH IVUS). Concerning geometrical plaque data, diabetic patients showed more plaques on MSCT (7.1 ± 3.2 vs 4.9 ± 3.2 in non-diabetic patients, P = .01). On gray-scale IVUS, diabetes was associated with a larger plaque burden (48.7 ± 10.7% vs 40.0 ± 12.1%, P = .003). Concerning plaque composition, diabetes was associated with more calcified plaques on MSCT (52% vs 24%). Relatively more fibrocalcific plaques in diabetic patients (29% versus 9%) were observed on VH IVUS. Moreover, these plaques contained more necrotic core (10.8 ± 5.9% vs 8.6 ± 5.2%, P = .01). Conclusion: A higher plaque extent and more calcified lesions were observed in diabetic patients on MSCT. The findings were confirmed on gray-scale and VH IVUS. Thus, MSCT may potentially be used to explore patterns of coronary atherosclerosis in diabetic patients.

Original languageEnglish
Pages (from-to)376-383
Number of pages8
JournalJournal of Nuclear Cardiology
Issue number3
Publication statusPublished or Issued - 2009
Externally publishedYes


  • Atherosclerosis
  • Computed tomography (CT)
  • Diabetes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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