Understanding physiology by using quantitative magnetic resonance perfusion imaging

Lalith S B Jesuthasan, Joseph B. Selvanayagam

Research output: Contribution to journalArticlepeer-review


Cardiac magnetic resonance (CMR) perfusion imaging enables precise quantitation of myocardial blood flow and has been validated in animal models. Myocardial perfusion imaging using a T1-sensitive imaging sequence during the first pass bolus injection of a gadolinium-based contrast agent remains the most robust and extensively studied to date. Myocardial blood flow could be calculated from signal intensity curves utilizing a tracer kinetic model or a model-independent deconvolution method. Quantitative CMR perfusion imaging has provided pathophysiologic insights in epicardial coronary artery disease, microvascular disease, and cardiomyopathy. Imaging at higher field strength, for both CMR first-pass perfusion and myocardial blood oxygen level-dependent imaging, is likely to advance quantitative myocardial perfusion in the future.

Original languageEnglish
Pages (from-to)130-137
Number of pages8
JournalCurrent Cardiovascular Imaging Reports
Issue number2
Publication statusPublished or Issued - 2009

ASJC Scopus subject areas

  • Histology
  • Applied Microbiology and Biotechnology
  • Cell Biology

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