TY - JOUR
T1 - Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume
AU - Nelson, Adam J.
AU - Worthley, Matthew
AU - Psaltis, Peter J.
AU - Carbone, Angelo
AU - Dundon, Benjamin K.
AU - Dundon, Rae F.
AU - Piantadosi, Cynthia
AU - Lau, Dennis H.
AU - Sanders, Prashanthan
AU - Wittert, Gary A.
AU - Worthley, Stephen G.
N1 - Funding Information:
Mr Adam Nelson is supported by the Florey Medical Research Foundation, University of Adelaide. Dr Peter Psaltis and Dr Ben Dundon are supported by the National Health and Medical Research Council of Australia, the National Heart Foundation of Australia and the Royal Adelaide Hospital through post-graduate medical research scholarships. Dr Dennis Lau is supported by the Earl Bakken Electrophysiology Scholarship, University of Adelaide, a Kidney Health Australia biomedical research scholarship and Postgraduate Research Scholarship from the National Health and Medical Research Council of Australia. Dr Prashanthan Sanders and Dr Stephen Worthley supported by the National Heart Foundation of Australia. This research work is, in part, supported by research grant-in-aid from the National Heart Foundation (G O7A 3086).
PY - 2009
Y1 - 2009
N2 - Background: Pericardial adipose tissue (PAT) has been shown to be an independent predictor of coronary artery disease. To date its assessment has been restricted to the use of surrogate echocardiographic indices such as measurement of epicardial fat thickness over the right ventricular free wall, which have limitations. Cardiovascular magnetic resonance (CMR) offers the potential to noninvasively assess total PAT, however like other imaging modalities, CMR has not yet been validated for this purpose. Thus, we sought to describe a novel technique for assessing total PAT with validation in an ovine model. Methods: 11 merino sheep were studied. A standard clinical series of ventricular short axis CMR images (1.5T Siemens Sonata) were obtained during mechanical ventilation breath-holds. Beginning at the mitral annulus, consecutive end-diastolic ventricular images were used to determine the area and volume of epicardial, paracardial and pericardial adipose tissue. In addition adipose thickness was measured at the right ventricular free wall. Following euthanasia, the paracardial adipose tissue was removed from the ventricle and weighed to allow comparison with corresponding CMR measurements. Results: There was a strong correlation between CMR-derived paracardial adipose tissue volume and ex vivo paracardial mass (R2 = 0.89, p < 0.001). In contrast, CMR measurements of corresponding RV free wall paracardial adipose thickness did not correlate with ex vivo paracardial mass (R2 = 0.003, p = 0.878). Conclusion: In this ovine model, CMR-derived paracardial adipose tissue volume, but not the corresponding and conventional measure of paracardial adipose thickness over the RV free wall, accurately reflected paracardial adipose tissue mass. This study validates for the first time, the use of clinically utilis d CMR sequences for the accurate and reproducible assessment of pericardial adiposity. Furthermore this non-invasive modality does not use ionising radiation and therefore is ideally suited for future studies of PAT and its role in cardiovascular risk prediction and disease in clinical practice.
AB - Background: Pericardial adipose tissue (PAT) has been shown to be an independent predictor of coronary artery disease. To date its assessment has been restricted to the use of surrogate echocardiographic indices such as measurement of epicardial fat thickness over the right ventricular free wall, which have limitations. Cardiovascular magnetic resonance (CMR) offers the potential to noninvasively assess total PAT, however like other imaging modalities, CMR has not yet been validated for this purpose. Thus, we sought to describe a novel technique for assessing total PAT with validation in an ovine model. Methods: 11 merino sheep were studied. A standard clinical series of ventricular short axis CMR images (1.5T Siemens Sonata) were obtained during mechanical ventilation breath-holds. Beginning at the mitral annulus, consecutive end-diastolic ventricular images were used to determine the area and volume of epicardial, paracardial and pericardial adipose tissue. In addition adipose thickness was measured at the right ventricular free wall. Following euthanasia, the paracardial adipose tissue was removed from the ventricle and weighed to allow comparison with corresponding CMR measurements. Results: There was a strong correlation between CMR-derived paracardial adipose tissue volume and ex vivo paracardial mass (R2 = 0.89, p < 0.001). In contrast, CMR measurements of corresponding RV free wall paracardial adipose thickness did not correlate with ex vivo paracardial mass (R2 = 0.003, p = 0.878). Conclusion: In this ovine model, CMR-derived paracardial adipose tissue volume, but not the corresponding and conventional measure of paracardial adipose thickness over the RV free wall, accurately reflected paracardial adipose tissue mass. This study validates for the first time, the use of clinically utilis d CMR sequences for the accurate and reproducible assessment of pericardial adiposity. Furthermore this non-invasive modality does not use ionising radiation and therefore is ideally suited for future studies of PAT and its role in cardiovascular risk prediction and disease in clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=67651046978&partnerID=8YFLogxK
U2 - 10.1186/1532-429X-11-15
DO - 10.1186/1532-429X-11-15
M3 - Article
C2 - 19416534
AN - SCOPUS:67651046978
SN - 1097-6647
VL - 11
JO - Journal of Cardiovascular Magnetic Resonance
JF - Journal of Cardiovascular Magnetic Resonance
IS - 1
M1 - 15
ER -