TY - JOUR
T1 - Vitamin D
T2 - Do we get enough?: A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe
AU - Brouwer-Brolsma, E. M.
AU - Bischoff-Ferrari, H. A.
AU - Bouillon, R.
AU - Feskens, E. J M
AU - Gallagher, C. J.
AU - Hypponen, E.
AU - Llewellyn, D. J.
AU - Stoecklin, E.
AU - Dierkes, J.
AU - Kies, A. K.
AU - Kok, F. J.
AU - Lamberg-Allardt, C.
AU - Moser, U.
AU - Pilz, S.
AU - Saris, W. H.
AU - Van Schoor, N. M.
AU - Weber, P.
AU - Witkamp, R.
AU - Zittermann, A.
AU - De Groot, L. C P G M
N1 - Funding Information:
Dr Llewellyn is supported by the UK National Institute for Health Research (NIHR)-funded Peninsula Collaboration for Leadership in Applied Health Research and Care. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health. This work is also supported by grants to Dr Llewellyn from the Alzheimer's Association (NIRG-11-200737), the James Tudor Foundation, the Sir Halley Stewart Trust, the Norman Family Charitable Trust, Lord Clinton's Charitable Trust, the Royal Devon & Exeter Foundation Trust, the Peninsula Medical School Foundation and the Age Related Diseases and Health Trust. Brouwer-Brolsma is financially supported by Graduate School VLAG.
PY - 2013/5
Y1 - 2013/5
N2 - On September 29, 2011, acknowledged experts in the field of vitamin D, mainly European, were brought together in order to discuss the recent scientific advances in relation to vitamin D: the current requirements and associations with various health outcomes. In this article, the discussions resulting from the meeting are summarized. Introduction: Several groups at risk for developing vitamin D insufficiency have been identified. Accordingly, reviews indicate that a significant percentage of the population worldwide have serum 25-hydroxyvitamin D levels below 50 nmol/l. In addition to the role of vitamin D in bone health, recent studies suggest that it may play a pivotal role in other systems, e.g., the cardiovascular system, pancreas, muscle, immune system and brain. Most evidence, however, is obtained from observational studies and yet inconclusive. Methods: To exchange and broaden knowledge on the requirements for vitamin D and its effect on various health outcomes, a workshop entitled "Vitamin D Expert Meeting: Do we get enough?", was organized. Results: Despite low vitamin D levels worldwide, consensus on the definition of deficiency is not yet reached. In order to define cut-off points for vitamin D whilst taking into account extraskeletal health effects, randomized controlled trials in these fields are warranted. The experts do emphasize that there is evidence to suggest an important role for vitamin D in the maintenance of optimal bone health at all ages and that vitamin D supplementation, in most studies co-administered with calcium, reduces fracture risk in the senior population. Conclusion: To reach a serum 25-hydroxyvitamin D level of 50 nmol/l older adults aged ≥65 years are therefore recommended to meet a mean daily vitamin D intake of 20 μg (800 IU), which is best achieved with a supplement.
AB - On September 29, 2011, acknowledged experts in the field of vitamin D, mainly European, were brought together in order to discuss the recent scientific advances in relation to vitamin D: the current requirements and associations with various health outcomes. In this article, the discussions resulting from the meeting are summarized. Introduction: Several groups at risk for developing vitamin D insufficiency have been identified. Accordingly, reviews indicate that a significant percentage of the population worldwide have serum 25-hydroxyvitamin D levels below 50 nmol/l. In addition to the role of vitamin D in bone health, recent studies suggest that it may play a pivotal role in other systems, e.g., the cardiovascular system, pancreas, muscle, immune system and brain. Most evidence, however, is obtained from observational studies and yet inconclusive. Methods: To exchange and broaden knowledge on the requirements for vitamin D and its effect on various health outcomes, a workshop entitled "Vitamin D Expert Meeting: Do we get enough?", was organized. Results: Despite low vitamin D levels worldwide, consensus on the definition of deficiency is not yet reached. In order to define cut-off points for vitamin D whilst taking into account extraskeletal health effects, randomized controlled trials in these fields are warranted. The experts do emphasize that there is evidence to suggest an important role for vitamin D in the maintenance of optimal bone health at all ages and that vitamin D supplementation, in most studies co-administered with calcium, reduces fracture risk in the senior population. Conclusion: To reach a serum 25-hydroxyvitamin D level of 50 nmol/l older adults aged ≥65 years are therefore recommended to meet a mean daily vitamin D intake of 20 μg (800 IU), which is best achieved with a supplement.
KW - Bone
KW - Cognition
KW - Diabetes
KW - Muscle
KW - Requirements
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84885020653&partnerID=8YFLogxK
U2 - 10.1007/s00198-012-2231-3
DO - 10.1007/s00198-012-2231-3
M3 - Review article
C2 - 23229471
AN - SCOPUS:84885020653
SN - 0937-941X
VL - 24
SP - 1567
EP - 1577
JO - Osteoporosis International
JF - Osteoporosis International
IS - 5
ER -