Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

T. J. Green, C. Murray Skeaff, J. E.P. Rockell, B. J. Venn, A. Lambert, J. Todd, G. L. Khor, S. P. Loh, S. Muslimatun, R. Agustina, S. J. Whiting

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79 Citations (Scopus)


Objective: To describe the vitamin D status of women living in two Asian cities, - Jakarta (6°S) and Kuala-Lumpur (2°N), to examine the association between plasma 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations, and to determine a threshold for plasma 25-hydroxyvitamin D above which there is no further suppression of PTH. Also, to determine whether dietary calcium intake influences the relationship between PTH and 25-hydroxyvitamin D. Design: Cross-sectional. Setting: Jakarta, Indonesia and Kuala Lumpur, Malaysia. Participants: A convenience sample of 504 non-pregnant women 18-40 years. Main measures: Plasma 25-hydroxyvitamin D and PTH. Results: The mean 25-hydroxyvitamin D concentration was 48nmol/l. Less than 1% of women had a 25-hydroxyvitamin D concentration indicative of vitamin D deficiency (<17.5 nmol/l); whereas, over 60% of women had a 25-hydroxyvitamin D concentration indicative of insufficiency (<50 nmol/l). We estimate that 52 nmol/l was the threshold concentration for plasma 25-hydroxyvitamin D above which no further suppression of PTH occurred. Below and above this concentration the slopes of the regression lines were -0.18 (different from 0; P=0.003) and -0.01 (P=0.775), respectively. The relation between vitamin D status and parathyroid hormone concentration did not differ between women with low, medium or high calcium intakes (P=0.611); however, even in the highest tertile of calcium intake, mean calcium intake was only 657 mg/d. Conclusion: On the basis of maximal suppression of PTH we estimate an optimal 25-hydroxyvitamin D concentration of ∼ 50 nmol/l. Many women had a 25-hydroxyvitamin D below this concentration and may benefit from improved vitamin D status.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalEuropean Journal of Clinical Nutrition
Issue number3
Publication statusPublished or Issued - Mar 2008
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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