Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

Lisa J. Moran; Manny Noakes; Gary A. Wittert; Peter M. Clifton; Robert J. Norman

doi:10.1016/j.rbmo.2012.07.013

Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

Lisa J. Moran, Manny Noakes, Gary A. Wittert, Peter M. Clifton, Robert J. Norman

Nutrition, Diabetes And Gut Health

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss.

Original language	English
Pages (from-to)	500-503
Number of pages	4
Journal	Reproductive BioMedicine Online
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.rbmo.2012.07.013
Publication status	Published or Issued - Nov 2012

Keywords

cardiovascular disease
inflammation
polycystic ovary syndrome
weight loss

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology
Developmental Biology

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10.1016/j.rbmo.2012.07.013

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title = "Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome",

abstract = "Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss.",

keywords = "cardiovascular disease, inflammation, polycystic ovary syndrome, weight loss",

author = "Moran, {Lisa J.} and Manny Noakes and Wittert, {Gary A.} and Clifton, {Peter M.} and Norman, {Robert J.}",

note = "Funding Information: This work was supported by the Australian Federation of University Women Postdoctoral Grants, a National Health and Medical Research Council Program Grant, the University of Adelaide Faculty of Health Sciences Small Research Grants Scheme, Colin Matthews Research Grants for Clinically Based Research and the Commonwealth Scientific and Industrial Research Organisation Human Nutrition. The authors acknowledge Unilever for assistance with study supplies. The authors thank Rebecca Thomson, Catherine Yandell, Julia Weaver, Vanessa Courage, Rosemary McArthur, Ruth Pinches, Sue Evans, Deborah Roffe, Mark Mano and Candita Sullivan for their assistance.",

year = "2012",

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doi = "10.1016/j.rbmo.2012.07.013",

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AU - Clifton, Peter M.

AU - Norman, Robert J.

N1 - Funding Information: This work was supported by the Australian Federation of University Women Postdoctoral Grants, a National Health and Medical Research Council Program Grant, the University of Adelaide Faculty of Health Sciences Small Research Grants Scheme, Colin Matthews Research Grants for Clinically Based Research and the Commonwealth Scientific and Industrial Research Organisation Human Nutrition. The authors acknowledge Unilever for assistance with study supplies. The authors thank Rebecca Thomson, Catherine Yandell, Julia Weaver, Vanessa Courage, Rosemary McArthur, Ruth Pinches, Sue Evans, Deborah Roffe, Mark Mano and Candita Sullivan for their assistance.

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Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

Abstract

Keywords

ASJC Scopus subject areas

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